The following services are offered in partnership with the Alberta Glycomics Centre. For more information about these services, please contact Elizabeth Nanak firstname.lastname@example.org.
- Building Blocks
- Sugar Nucleotides
- Kdo Glycosides
- Solid-phase oligosaccharide synthesis
- Chemoenzymatic Synthesis
- Solid-Phase Synthesis using your Building Blocks
- Glycoconjugation Methods
- Glycoconjugate Synthesis
Glycan Structure Analysis
We offer a unique set of services and expertise for solving your problems in glycomics research. We are experienced in the analysis of complex glycans and glycoproteins and can provide routine analysis or help to interpret complex data. Our services include:
- Routine characterization of oligosaccharide samples for QC and analysis
- Complex structure determination, including high-resolution conformational analysis and protein-carbohydrate complexes
- 1D/2D NMR (300, 400, 500, 600, 700 MHz), STD-NMR
- Compositional analysis (stoichiometry) of polysaccharides
- Mass spectrometry
- Oligosaccharide/Glycan sequencing
- Determination of unusual or modified glycan structures
- Nano-ES, MALDI TOF/TOF, FT-ICR
- Molecular modeling
- Molecular dynamics of glycoproteins and protein-carbohydrate complexes
- AMBER (GLYCAM), Gaussian
- Biomolecular interactions
- SPR (BIAcore), Microcalorimetry
- Glycan analysis is often complex, and can require advanced training. We will work with you to interpret data from even your most complex samples.
The Glycan Screening Facility, operated by the Alberta Glycomics Centre of the University of Alberta, is a state-of-the-art facility offering carbohydrate library screening capabilities.
The Glycan Screening Facility and its expert staff employ advanced electrospray ionization mass spectrometry (ESI-MS) instrumentation and methods to screen carbohydrate libraries (as well as other classes of compounds) against target proteins to identify novel inhibitors and natural receptors that may be exploited for the development new and effective treatments for a variety of bacterial and viral infections as well as other diseases. Our carbohydrate collection includes over 250 compounds (including ABH and Lewis histogroup antigens, human milk oligosaccharides, gangliosides, and plant and bacterial oligosaccharides). The Glycan Screening Facility is dedicated to developing novel ESI-MS methods which allow identification, characterization, and quantification of protein-carbohydrate interactions in vitro. Researchers may access the Glycan Screening Facility through research collaborations or on a fee-for-service basis.
GlycoNet, in partnership with the Alberta Glycomics Centre and the Derda Research Group at the University of Alberta, has launched its latest core service—the 48-Hour Discovery. This accelerated service is designed to help academia and industry in molecular discovery in the areas of therapeutics, diagnostics, and probe development.
The 48-Hour Discovery allows clients to mail in a protein solution for analysis. Forty-eight hours later, scientists provide a molecular breakdown of the protein as well as a prediction of its affinity and cross-reactivity with other targets.
In addition, the 48-Hour Discovery offers risk management, expert analysis, and long-term partnership with the Network’s academic and industrial collaborators.
If you have a molecular target in mind, please contact us.