David R. Rose completed a B.A. in Biophysics from the University of Pennsylvania in 1977, followed by a DPhil at Ocford University in 1981 under Sir David Phillips. From 1981-1984, he was a postdoctoral fellow with Gregory Petsko in the Chemistry Department at MIT. His independent career started at the National Research Council in Ottawa, rising to the post of Senior Scientist and Group Leader. Beginning in 1991, the core of David’s career was at the Ontario Cancer Institute/University of Toronto for almost 20 years. In addition to research and supervision, he took on administrative roles in the graduate program of his Department and in the Research Institute. In 2009, David was recruited to the University of Waterloo to be Chair of the Biology Department. He has contributed many structures and publications to the field of macromolecular crystallography. His main area of research has been in glycobiology, particularly the interactions between proteins and carbohydrates, and the mechanism of action of enzymes with activities towards polysaccharides. He has published over 120 peer-reviewed papers (Scopus h-index of 34). Many of these are in top journals in biochemistry and structural biology, as well as PNAS, Science and J Biol Chem. David published a series of papers over many years characterizing the details of an important enzyme in the N-glycosylation pathway, alpha-mannosidase II, an enzyme which, in addition to its core importance in glycoprotein synthesis, is an attractive target for the development of anti-cancer compounds. More recently, his research has focused on the human enzymes involved in degrading food starch structures into nutritional glucose. This work has medical relevance to nutritional disorders and intolerances, diabetes and obesity.
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