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Série de webinaires

GlycoNet/ACS Joint Webinars:
     April, 2021
     May, 2021 (TBA)
     June, 2021 (TBA)
Anciens Webinaires de GlycoNet

GlycoNet offers webinars on diverse topics ranging from scientific research to professional development, technical workshops, and focused seminars for the science community. In September 2020, GlycoNet has joined forces with the Carbohydrate Chemistry Division of American Chemical Society to host webinars featuring renowned researchers across North America and Europe. In addition to Q&A period, each event is followed by an informal “networking session” at the end of the presentations, giving the audience opportunities to learn more about the presenters and their research.

Prochains Webinaires

APRIL, 2021

S4E15: April 21, 11 am – 12:30 pm MT | Inscrivez-vous ici
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Catherine Grimes
Professor, University of Delaware

Peptidoglycan and you, perfect together?

Catherine Leimkuhler Grimes obtained a BS in Chemistry in 2001 from Villanova University. She obtained her masters in 2003 from Princeton University and PhD from Harvard University in 2006. Her graduate work was conducted under the guidance of Professor Dan Kahne, which focused on synthesizing glycopeptides to combat antibiotic resistance. From 2006 to 2011, Catherine was a HHMI and Cancer Research Institute Postdoctoral fellow in the laboratories of Erin O’Shea (Harvard University, Molecular and Cellular Biology) and Daniel Podolosky (Massachusetts General Hospital).

Catherine joined the University of Delaware’s Chemistry and Biochemistry Department as an Assistant Professor of Chemistry and Biochemistry in 2011. She was appointed a joint faculty in the Department of Biological Sciences in 2012 and promoted to Professor in September 2019. Her research program focuses on the development and chemical synthesis of small molecule carbohydrate probes that mimic intermediates of bacterial cell wall biosynthesis and bacterial-host immune recognition.

 
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Abhishek Bhattacherjee
Post-doctoral researcher (Macauley Lab), University of Alberta

Role of CD33 isoforms in Alzheimer’s Disease Susceptibility

Abhishek completed his PhD from university of Calcutta, India in biophysics, molecular biology, and bioinformatics. During his doctoral studies, he worked on different aspects of protein glycation and nano-therapeutics in context to diabetic mellitus. His interdisciplinary research area focused on biochemistry, biophysics and drug development. After completion of his doctoral work, he joined University of Alberta (Faculty of Agricultural, Life & Environmental Sciences), as post-doctoral fellow with Dr. Mirko Betti. During his postdoctoral work, he worked on different aspects of glycol-biology, biochemistry and microbiology in correlation with functional product development. He did his second post-doctoral study with Dr. Matthew Macauley (Department of Chemistry, University of Alberta) on neuro-degenerative disease and specially focusing on the role of siglec in Alzheimer’s disease. At the moment he is working as research associate in Macauley Lab and leading the project where he tries to explore the role of CD33 protein in Alzheimer’s disease.

S4E16: April 28, 11 am – 12:30 pm MT | Register ici.
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Alisdair Boraston
Associate Professor, University of Victoria

O-glycopeptidases: the complex substrate recognition determinants of peptidases with a sweet tooth

Alisdair B. Boraston received his BSc. in Microbiology and Immunology from the University of British Columbia (UBC) in 1993. He obtained his Ph.D. in Microbiology and Immunology under the supervision of Professors Doug Kilburn and Tony Warrren at UBC in 2000 then, after a brief post-doctoral research appointment in the UBC Biotechnology Laboratory, he spent 1.5 years in England training as an NSERC-funded Post-Doctoral Fellow in the York Structural Biology Laboratory, University of York, UK, under the supervision of Professor Gideon Davies. In 2003, he began a position in the Department of Biochemistry and Microbiology at The University of Victoria as an Assistant Professor and was ultimately promoted to Professor in 2014. Group research interest is in structural glycobiology and its application to the analysis of protein-carbohydrate interactions in enzymes that modify carbohydrates or proteins that non-catalytically bind them. One major area of investigation is molecular pathogenesis whereby the roles of bacterial proteins in recognizing and/or modifying host glycans during infection are examined. A second key topic of study is the enzymatic breakdown of marine and terrestrial plant cell walls by microbes and how the unique building blocks of these polymerized sugars are funneled through novel metabolic pathways. Recognitions include an EWR Steacie Memorial Fellowship (2012) and he held the Tier 2 Canada Research Chair in Molecular Interactions (2003-2013).

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Adam Kositzke
Graduate Student (Jiang Lab), University of Wisconsin-Madison

Elucidating the substrate binding mode of O-GlcNAc transferase toward O-GlcNAcase using electrophilic probes

Adam Kositzke earned his BS in biology and chemistry from the University of Wisconsin Oshkosh, where he elucidated the X-ray crystal structure of a bacterial glycoside hydrolase under the guidance of Dr. Christopher Bianchetti. Following that, Adam joined the lab of Dr. Jiaoyang Jiang at the University of Wisconsin Madison in 2016, where he characterized the substrate recognition of the human O-GlcNAc transferase (OGT) toward its protein substrate, O-GlcNAcase (OGA), and developed an in-house galactosyltransferase assay to detect recombinant and cellular protein O-GlcNAcylation.

Stay tuned for more speakers in May! Follow us on social media to get our latest announcements:

Anciens Webinaires

Saison 1 (avril – juin 2020):

Numéro du webinaire Numéro du webinaire dans la saison Conférenciers & titres des présentations (anglais seulement)
1 1 Dr. Christopher Cairo, Associate Professor, University of Alberta
Inhibitors of human neuraminidase enzymes as probes in glycobiology
Mirat Sojitra, Graduate Student, University of Alberta
Genetically encoded multivalent liquid glycan array (LiGA)
2 2 Dr. Andrew Lees, Founder and Scientific Director, Fina Biosolutions
Simplifying conjugation: ready to conjugate CRM197 carrier protein
3 3 Dr. Robert Woods, Professor, University of Georgia
3D models of glycosylated SARS-CoV-2 protein suggest challenges for vaccine development
Dr. Jolene Garber, Post-Doctoral Fellow, University of British Columbia Okanagan
Campylobacter jejuni chemotaxis and metabolism of fucose
4 4 Dr. Lori Yang, CEO & CSO, Lectenz Bio
Lectenz and GlycoSense: novel tools for glycan detection and analysis
5 5 Dr. Matt Macauley, Assistant Professor, University of Alberta
Modulation of microglia by the glycan-binding protein CD33
Carla Eymard, Graduate Students, Institut de recherches cliniques de Montreal
From free radical chemistry to novel classes of bioactive modified furanosides
6 6 Dr. Anne Krook, Practical Workplace Advice
A guide to non-academic job search
7 7 Dr. Karla Williams, Assistant Professor, University of British Columbia
Polysialic acid as a prognostic marker in breast cancer
Sadia Rahmani, Graduate Student, Ryerson University
O-GlcNAc modification affects clathrin-coated pit assembly and efficiency at the plasma membrane
8 8 Panel Discussion ft. Drs. David Vocadlo, Stephanie White, and Kaley Wilson
What I wish I knew: a chat with researchers, patent experts and entrepreneurs
9 9 Dr. Lynne Howell, Professor, The Hospital for Sick Children
Exopolysaccharide biosynthesis
Dr. Ryan Sweeney, Post-Doctoral Fellow, University of Alberta
Development of an active site titration reagent for amylases
10 10 Andrew MacIsaac, CEO, Applied Pharmaceutical Innovation
Navigating commercial development with API
11 11 Dr. Molly Shoichet, Professor, University of Toronto
Polysaccharide hydrogels enable local drug and cell delivery
Akay Akohwarien, Research Technician, University of Saskatchewan
Designing novel chemical tools to study β-glucocerebrosidase: a relevant biomarker and therapeutic target in Parkinson's Disease
12 12 Sabrina Sassi, TEDx Speaker
Leveraging TED to spread your research ideas: how and why researchers are doing it

Saison 2 (juillet – août 2020)

Numéro du webinaire Numéro du webinaire dans la saison Conférenciers & titres des présentations (anglais seulement)
13 1 Dr. Parastoo Azadi, Executive Director, Analytical Services, Complex Carbohydrate Research Centre
Glycobiology of SARS-CoV2 and its implications for vaccine development
Dr. Supriya Dey, Post-Doctoral Fellow, Harvard University
Programmable one-pot synthesis of heparin and heparin-related anticoagulants
14 2 Dr. Robert Ben, Professor, University of Ottawa
Improving the efficacy of modern cellular therapies
Dr. François Le Mauff, Post-Doctoral Fellow, McGill University
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for aspergillus fumigatus biofilm formation
15 3 Dr. David Pamer, Professor, University of Saskatchewan
Writing an effective grant proposal
16 4 Dr. David Kwan, Assistant Professor, Concordia University
A set of chemical biology tools to probe and inhibit cellular glycosyltransferases
Shermaine Sy, B.Sc, University of Alberta
Development of a bead-based assay for ABO antibody detection: creating a new tool for the clinical laboratory
17 5 Drs. Kate Pratt and Jonathon Simmons, Academic Success Centre, University of Alberta
A workshop for scientific writers
18 6 Dr. Chris Phenix, Assistant Professor, University of Saskatchewan
Chemical tools for studying glucosidase activity in complex biological samples
F. Ifthiha Mohideen, Graduate Student, Concordia University
An engineered in vitro enzymatic pathway for the anticancer anthracycline deoxysugars: TDP-L-acosamine and TDP-L-daunosamine
19 7 Dr. Rebecca Davis, Associate Professor, University of Manitoba
Computational approaches for designing small molecule inhibitors
20 8 Dr. Robert Britton, Professor, Simon Fraser University
De novo synthesis of nucleoside analogues for medicinal chemistry purposes
Dr. Kristen Low, Post-Doctoral Fellow, Agriculture and Agri-Food Canada
Bioprospecting CAZymes from intestinal microbiomes for the tailored degradation of non-starch dietary polysaccharides

Saison 3 (septembre – décembre 2020)

Numéro du webinaire Numéro du webinaire dans la saison Conférenciers & titres des présentations (anglais seulement)
21 1 Dr. Lara Mahal, Professor, University of Alberta
Exploring the roles of glycosylation in infection and immunity
Dr. Peter Rahfeld, Research Associate, University of British Columbia
From gut to blood: how to make universal donor blood
22 2 Dr. Mary Cloninger, Professor, Montana State University
Lactose-functionalized dendrimers and dendritic polyglycerols for binding to galectin-3
Dr. Pumtiwitt McCarthy, Associate Professor, Morgan State University
Bacterial capsule polymerases as tools to improve human health
23 3 Dr. Warren Wakarchuk, Professor, University of Alberta
Protein engineering of 21st century drugs through the application of synthetic biology
Dr. Landon Edgar, Post-doctoral fellow, Scripps Research
Invigorating T cells through carbohydrate editing
24 4 Dr. Theresa M. Reineke, Professor, University of Minnesota
Glycopolymers promote in vivo and ex vivo delivery of functional nucleic acids
Dr. Jodi Hadden-Perilla, Assistant Professor, University of Delaware
The fuzzy boundaries of carbohydrate binding sites
25 5 Dr. Mark Nitz, Professor, University of Toronto
Exploring a low affinity probe for the biofilm-associated poly-N-acetylglycosamine exopolysaccharide
Dr. Sandra Irmisch, Research Associate, University of British Columbia
A novel anti-diabetic compound from plants: biosynthesis, gene discovery, and metabolic engineering of montbretin A
26 6 Dr. Mingdi Yan, Professor, University of Massachusetts Lowell
Carbohydrate-conjugated fluorescence turn-on azide probes for imaging cells and bacteria
Dr. Jessica Kramer, Assistant Professor, University of Utah
Synthetic mucins: from new chemical routes to engineered cells
27 7 Dr. David Vocadlo, Professor, Simon Fraser University
Fluorescence-quenched substrates for monitoring glycoside hydrolase activities in mammalian cells
Dr. Simonetta Sipione, Professor, University of Alberta
Gangliosides in neurodegeneration and neuroinflammation

Season 4 (January – April 2021)

Numéro du webinaire Numéro du webinaire dans la saison Conférenciers & titres des présentations (anglais seulement)
28 1 Dr. Geert-Jan Boons, Professor, University of Georgia
Probing receptor and co-receptor specificities of coronaviruses using chemo-enzymatic synthesis and glycoarray technology
Dr. Hien Nguyen, Professor, Wayne State University
Discovery of sulfated glycopolymers as potent inhibitors of heparanase and SARS-CoV-2
29 2 Dr. Jennifer Kohler, Associate Professor, University of Texas Southwestern Medical Center
Intestinal fucose, in sickness and in health
Catherine Alex, Graduate Student, University of Missouri-St. Louis
Methodologies for stereocontrolled mannosylation with acidic and/or aminosugars
30 3 Dr. Jia Niu, Assistant Professor, Boston College
A general approach to early-stage O-sulfation of carbohydrates and peptides
Erum Razvi, Graduate Student, SickKids Hostpial
Identifying the role of the Pseudomonas aeruginosa PelA hydrolase in Pel polysaccharide biosynthesis
31 4 Dr. Chantelle Capicciotti, Assistant Professor, Queen's University
Glycan remodelling with chemical tools to probe glycan-protein interactions
Jiayi Li, Graduate Student, Wayne State University
Phenanthroline-catalyzed glycosylation: expansion of substrate scope and investigation of mechanism
32 5 Dr. John Hanover, Chief, Laboratory of Cell and Molecular Biology, NIDDK at National Institutes of Health
O-GlcNAc and Disease
Matthew Deen, Graduate Student, Simon Fraser University
A light in the darkness: GBA1-FQ6 a new tool for studying glucocerebrosidase a Parkinson’s disease associated glycoside hydrolase
33 6 Dr. Sabine Flitsch, Professor, Manchester Institute of Biotechnology
Synthetic and analytical tools for glycobiology
Shaochi Wang, Graduate Student, University of Maryland
Development of colorimetric and fluorometric oligosaccharide probes enabling high-throughput screening for glycosyl hydrolase enzymes
34 7 Dr. Charlie Fehl, Assistant Professor, Wayne State University
Real-time chemical tools for dynamic O-GlcNAc glycoprotein functions
Dr. Adam Forman, Post-doctoral Researcher, University of Toronto
Development of substrates to characterize PgaB, a hydrolase involved in the synthesis of the biofilm exopolysaccharide dPNAG
35 8 Dr. Kelly McNagny, Professor, University of British Columbia
CD34-type sialomucins: general regulators of cell adhesion and migration and targets for cancer immunotherapy
Dr. Jicheng Zhang, Post-doctoral Researcher, Wayne State University
Trisaccharides with specific sulfation sequences in modulating heparanase activity
36 9 Dr. Kamil Godula, Associate Professor, University of California San Diego
Functional polymeric glycomaterials for regulating stem cell differentiation
Kristina Klobucar, Graduate Student, McMaster University
A chemical screen for vancomycin antagonism uncovers probes of the Gram-negative outer membrane
37 10 Dr. Christoph Rademacher, Professor, University of Vienna
Application of glycomimetics for the development of topical vaccines
Jonathan Quirke, Graduate Student, University of Georgia
Glycosidase and glycosyltransferase transition state stabilization through substrate side chain restriction
38 11 Dr. Nicola Pohl, Professor, Indiana University Bloomington
How to Make Glycan Synthesis FAIR* (* Findable, Accessible, Interoperable and Reusable)
Hanna Ostapska, Graduate Student, McGill University
Exopolysaccharides in co-operative biofilm formation by A. fumigatus and P. aeruginosa
39 12 Wade Abbott, Research Scientist, Agriculture and Agri-Food Canada
Glyco-enabling tools for study of microbial glycan metabolism in agriculture
Daniel Ramirez, Graduate Student, Harvard University
Engineering a proximity-directed OGT to control O-GlcNAc signaling
40 13 Ben Swarts, Associate Professor, Central Michigan University
Commandeering mycobacterial carbohydrate metabolism for applications in tuberculosis research
Emily Rodrigues, Graduate Student, University of Alberta
Leveraging avidity of Siglec-ligand interactions with a versatile soluble Siglec scaffold
41 14 Lori West, Professor, University of Alberta
Bringing 21st century tools for ABO antibody detection into the clinical laboratory
Courtney Kondor, Graduate Student, Wayne State University
Development of photo-controlled sugar labeling reagents to track disease processes

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