GlycoNet/ACS Joint Webinars:
January, 2021
February, 2021
March, 2021 (TBA)
April, 2021 (TBA)
Anciens Webinaires de GlycoNet
Dr. Geert-Jan Boons is the UGA Foundation Distinguished Professor in Biochemical Sciences at the Department of Chemistry and the Complex Carbohydrate Research Center (CCRC) of the University of Georgia and Professor and Chair of the Department of Medicinal and Biological Chemistry of Utrecht University. He received a B.S. and Ph.D. in Chemistry from the Leiden University and spent seven years in the UK, first as a postdoctoral fellow at Imperial College, London, and the University of Cambridge, and then as a lecturer and professor at the University of Birmingham. In 1998, he joined the faculty of the Department of Chemistry and CCRC of the University of Georgia, and in 2015 he accepted a secondary academic appointment at Utrecht University. His group is developing methods for synthesizing exceptionally complex glycans and glycoconjugates that are being used for biological and biomedical explorations with a focus on infection, immunology and cancer.
Dr. Hien Nguyen joined University of Iowa as an Assistant Professor in 2009 and became an Associate Professor with tenure in 2013. In 2018, Dr. Nguyen joined Wayne State University. Before beginning his independent career, Prof. Nguyen was an NIH postdoctoral fellow in the laboratory of Prof. Barry Trost at Stanford University. He obtained his Ph.D. in Organic Chemistry under the direction of the late Prof. David Gin from University of Illinois at Urbana-Champaign and a B.S. in Chemistry from Tufts University in Boston, MA. One of the major programs in his lab is to develop well-defined, sulfated polymeric and oligomeric carbohydrate molecules as potent inhibitors of heparanase and SARS-CoV-2 for studying cancer metastasis, tumor cell invasion, diabetes, viral infection, and Alzheimer’s. His group also develops new catalytic methodologies for the stereoselective construction of alpha-1,2-cis glycosides, as well as developing catalytic and enanatioselective methods for the synthesis of fluorine-containing compounds.
Intestinal fucose, in sickness and in health
Dr. Jennifer Kohler completed her undergraduate degree in Chemistry at Bryn Mawr College. Her PhD studies, focused on the kinetics of protein-DNA interactions, were conducted in the laboratory of Prof. Alanna Schepartz, in the Chemistry Department at Yale University. From 2000-2004, Jennifer was an American Cancer Society postdoctoral fellow with Prof. Carolyn Bertozzi at the University of California, Berkeley. Research in the Kohler lab focuses on understanding the roles of glycoconjugates in a variety of biological systems.
Methodologies for stereocontrolled mannosylation with acidic and/or aminosugars
Catherine Alex graduated from Indian Institute of Science Education and Research Pune (IISER-P) with BSc-MSc degree in 2016. She did her thesis project in Dr. Raghavendra Kikkeri’s lab on the topic “Multivalent Homo and Heterogeneous Glycodendrimers Allow Sequence-Defined Carbohydrate-Protein Interactions.” She began her PhD program at the University of Missouri-St. Louis in fall 2016, where she joined the laboratory of Prof. Alexei V. Demchenko. Her research focuses on the synthesis of challenging beta-mannosidic linkages.
A general approach to early-stage O-sulfation of carbohydrates and peptides
Dr. Jia Niu obtained a B.S. degree (2005) and a M.S. degree (2008) from Tsinghua University in China. He then moved to the United States to pursue a PhD degree at Harvard University, working with Prof. David R. Liu on the enzyme-free translation and directed evolution of synthetic polymers. Dr. Niu joined the faculty of Boston College in 2017 after working as a postdoctoral scholar in the laboratories of Prof. Craig Hawker and Prof. Tom Soh at University of California, Santa Barbara. Currently, Dr. Niu and his group are focused on understanding functional roles of sulfation patterns in bioactive macromolecules, developing sustainable plastics using biobased building blocks, and the directed evolution of genome editors.
Title TBA
Erum Razvi received her BSc in Health Science at Wilfrid Laurier University. Currently, she is pursuing her PhD in Biochemistry under the supervision of Dr. P. Lynne Howell at the University of Toronto. In the Howell Lab at The Hospital for Sick Children, Erum studies Pseudomonas aeruginosa biofilms. The aim of Erum’s PhD project is to structurally characterize the deacetylase domain of the enzyme in P. aeruginosa, understand PelA’s role in vivo, and identify PelA deacetylase inhibitors from a high-throughput screen as a means of developing a novel therapeutic.
Title TBA
Dr. Chantelle Capicciotti received her PhD in Chemistry from the University of Ottawa in 2014 under the supervision of Prof. Robert Ben where she worked on designing small molecule carbohydrate-based ice recrystallization inhibitors as novel cryoprotectants. In 2014, she joined the laboratory of Prof. Geert-Jan Boons for post-doctoral research studies at the Complex Carbohydrate Research Center where she developed chemoenzymatic strategies to synthesize complex glycans. In 2018, she moved to Queen’s University, jointly appointed in the Departments of Chemistry and Biomedical and Molecular Sciences. Her research interests focus on understanding how glycans/glycoproteins interact with proteins at a cellular level to elicit biological function, and on developing glycan-based approaches for biomarker identification, disease diagnosis, imaging techniques, and cell-based therapies.
Title TBA
Jiayi Li received her BSc in Chemical Engineering from the University of Iowa in 2017. She joined Dr. Hien Nguyen’s lab at Wayne State University in 2017. Her current project is on phenanthroline-catalyzed stereoretentive glycosylation.
Synthetic and analytical tools for glycobiology
Sabine Flitsch graduated with a Diploma in Chemistry from the University of Münster (Germany) and obtained her DPhil in 1985 from the University of Oxford. She spent three years at the Massachusetts Institute of Technology, USA as a Research Fellow (with H. G. Khorana) before returning to the UK to hold academic positions at the Universities of Exeter, Oxford, Edinburgh and Manchester. She is currently Professor of Biological Chemistry at the University of Manchester with her research group housed at the Manchester Institute of Biotechnology (MIB).
Title TBA
Adam received his PhD in chemistry from the University of Toronto in 2020 under the supervision of Prof. Mark Nitz. He was born and raised in Toronto, and completed his BSc in 2011 at the University of Guelph, majoring in Biological & Pharmaceutical Chemistry and Mathematics. In 2014, he completed his MSc in chemistry at Guelph under the supervision of Dr. France-Isabelle Auzanneau, researching glycosylations at O-3 of GlcNAc. His current research in Nitz lab as a postdoctoral researcher revolves around developing substrates for bacterial enzymes which are responsible for the synthesis of biofilm exopolysaccharides.
Numéro du webinaire | Numéro du webinaire dans la saison | Conférenciers & titres des présentations (anglais seulement) |
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1 | 1 |
Dr. Christopher Cairo, Associate Professor, University of Alberta Inhibitors of human neuraminidase enzymes as probes in glycobiology Mirat Sojitra, Graduate Student, University of Alberta Genetically encoded multivalent liquid glycan array (LiGA) |
2 | 2 |
Dr. Andrew Lees, Founder and Scientific Director, Fina Biosolutions Simplifying conjugation: ready to conjugate CRM197 carrier protein |
3 | 3 |
Dr. Robert Woods, Professor, University of Georgia 3D models of glycosylated SARS-CoV-2 protein suggest challenges for vaccine development Dr. Jolene Garber, Post-Doctoral Fellow, University of British Columbia Okanagan Campylobacter jejuni chemotaxis and metabolism of fucose |
4 | 4 |
Dr. Lori Yang, CEO & CSO, Lectenz Bio Lectenz and GlycoSense: novel tools for glycan detection and analysis |
5 | 5 |
Dr. Matt Macauley, Assistant Professor, University of Alberta Modulation of microglia by the glycan-binding protein CD33 Carla Eymard, Graduate Students, Institut de recherches cliniques de Montreal From free radical chemistry to novel classes of bioactive modified furanosides |
6 | 6 |
Dr. Anne Krook, Practical Workplace Advice A guide to non-academic job search |
7 | 7 |
Dr. Karla Williams, Assistant Professor, University of British Columbia Polysialic acid as a prognostic marker in breast cancer Sadia Rahmani, Graduate Student, Ryerson University O-GlcNAc modification affects clathrin-coated pit assembly and efficiency at the plasma membrane |
8 | 8 |
Panel Discussion ft. Drs. David Vocadlo, Stephanie White, and Kaley Wilson What I wish I knew: a chat with researchers, patent experts and entrepreneurs |
9 | 9 |
Dr. Lynne Howell, Professor, The Hospital for Sick Children Exopolysaccharide biosynthesis Dr. Ryan Sweeney, Post-Doctoral Fellow, University of Alberta Development of an active site titration reagent for amylases |
10 | 10 |
Andrew MacIsaac, CEO, Applied Pharmaceutical Innovation Navigating commercial development with API |
11 | 11 |
Dr. Molly Shoichet, Professor, University of Toronto Polysaccharide hydrogels enable local drug and cell delivery Akay Akohwarien, Research Technician, University of Saskatchewan Designing novel chemical tools to study β-glucocerebrosidase: a relevant biomarker and therapeutic target in Parkinson's Disease |
12 | 12 |
Sabrina Sassi, TEDx Speaker Leveraging TED to spread your research ideas: how and why researchers are doing it |
Numéro du webinaire | Numéro du webinaire dans la saison | Conférenciers & titres des présentations (anglais seulement) |
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13 | 1 |
Dr. Parastoo Azadi, Executive Director, Analytical Services, Complex Carbohydrate Research Centre Glycobiology of SARS-CoV2 and its implications for vaccine development Dr. Supriya Dey, Post-Doctoral Fellow, Harvard University Programmable one-pot synthesis of heparin and heparin-related anticoagulants |
14 | 2 |
Dr. Robert Ben, Professor, University of Ottawa Improving the efficacy of modern cellular therapies Dr. François Le Mauff, Post-Doctoral Fellow, McGill University Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for aspergillus fumigatus biofilm formation |
15 | 3 |
Dr. David Pamer, Professor, University of Saskatchewan Writing an effective grant proposal |
16 | 4 |
Dr. David Kwan, Assistant Professor, Concordia University A set of chemical biology tools to probe and inhibit cellular glycosyltransferases Shermaine Sy, B.Sc, University of Alberta Development of a bead-based assay for ABO antibody detection: creating a new tool for the clinical laboratory |
17 | 5 |
Drs. Kate Pratt and Jonathon Simmons, Academic Success Centre, University of Alberta A workshop for scientific writers |
18 | 6 |
Dr. Chris Phenix, Assistant Professor, University of Saskatchewan Chemical tools for studying glucosidase activity in complex biological samples F. Ifthiha Mohideen, Graduate Student, Concordia University An engineered in vitro enzymatic pathway for the anticancer anthracycline deoxysugars: TDP-L-acosamine and TDP-L-daunosamine |
19 | 7 |
Dr. Rebecca Davis, Associate Professor, University of Manitoba Computational approaches for designing small molecule inhibitors |
20 | 8 |
Dr. Robert Britton, Professor, Simon Fraser University De novo synthesis of nucleoside analogues for medicinal chemistry purposes Dr. Kristen Low, Post-Doctoral Fellow, Agriculture and Agri-Food Canada Bioprospecting CAZymes from intestinal microbiomes for the tailored degradation of non-starch dietary polysaccharides |
Numéro du webinaire | Numéro du webinaire dans la saison | Conférenciers & titres des présentations (anglais seulement) |
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21 | 1 |
Dr. Lara Mahal, Professor, University of Alberta Exploring the roles of glycosylation in infection and immunity Dr. Peter Rahfeld, Research Associate, University of British Columbia From gut to blood: how to make universal donor blood |
22 | 2 |
Dr. Mary Cloninger, Professor, Montana State University Lactose-functionalized dendrimers and dendritic polyglycerols for binding to galectin-3 Dr. Pumtiwitt McCarthy, Associate Professor, Morgan State University Bacterial capsule polymerases as tools to improve human health |
23 | 3 |
Dr. Warren Wakarchuk, Professor, University of Alberta Protein engineering of 21st century drugs through the application of synthetic biology Dr. Landon Edgar, Post-doctoral fellow, Scripps Research Invigorating T cells through carbohydrate editing |
24 | 4 |
Dr. Theresa M. Reineke, Professor, University of Minnesota Glycopolymers promote in vivo and ex vivo delivery of functional nucleic acids Dr. Jodi Hadden-Perilla, Assistant Professor, University of Delaware The fuzzy boundaries of carbohydrate binding sites |
25 | 5 |
Dr. Mark Nitz, Professor, University of Toronto Exploring a low affinity probe for the biofilm-associated poly-N-acetylglycosamine exopolysaccharide Dr. Sandra Irmisch, Research Associate, University of British Columbia A novel anti-diabetic compound from plants: biosynthesis, gene discovery, and metabolic engineering of montbretin A |
26 | 6 |
Dr. Mingdi Yan, Professor, University of Massachusetts Lowell Carbohydrate-conjugated fluorescence turn-on azide probes for imaging cells and bacteria Dr. Jessica Kramer, Assistant Professor, University of Utah Synthetic mucins: from new chemical routes to engineered cells |
27 | 7 |
Dr. David Vocadlo, Professor, Simon Fraser University Fluorescence-quenched substrates for monitoring glycoside hydrolase activities in mammalian cells Dr. Simonetta Sipione, Professor, University of Alberta Gangliosides in neurodegeneration and neuroinflammation |
Numéro du webinaire | Numéro du webinaire dans la saison | Conférenciers & titres des présentations (anglais seulement) |
---|---|---|
28 | 1 |
Dr. Geert-Jan Boons, Professor, University of Georgia Probing receptor and co-receptor specificities of coronaviruses using chemo-enzymatic synthesis and glycoarray technology Dr. Hien Nguyen, Professor, Wayne State University Discovery of sulfated glycopolymers as potent inhibitors of heparanase and SARS-CoV-2 |
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