{"id":17172,"date":"2021-03-26T07:26:02","date_gmt":"2021-03-26T13:26:02","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=17172"},"modified":"2021-12-10T17:03:22","modified_gmt":"2021-12-11T00:03:22","slug":"funding-research-toward-treating-the-root-cause-of-neurodegenerative-disease","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/funding-research-toward-treating-the-root-cause-of-neurodegenerative-disease\/","title":{"rendered":"Tackling the root cause of neurodegenerative disease"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"17172\" class=\"elementor elementor-17172\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c1b6951 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c1b6951\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-638771fb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"638771fb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7455b33a\" data-id=\"7455b33a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-400f3c48 elementor-widget elementor-widget-spacer\" data-id=\"400f3c48\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b1f00d3 elementor-widget elementor-widget-text-editor\" data-id=\"3b1f00d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\"><strong>Tackling the root cause of neurodegenerative disease <\/strong><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79fbd1c elementor-widget elementor-widget-text-editor\" data-id=\"79fbd1c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Ali Chou \u2022 Posted: March 25, 2021<\/span><\/p><p style=\"text-align: center;\"><em>Professor and GlycoNet Investigator Simonetta Sipione\u2019s research awarded major grant from the Canadian Institutes of Health Research<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fa4c974 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fa4c974\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-79cfd430\" data-id=\"79cfd430\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-622f3ce2 elementor-widget elementor-widget-text-editor\" data-id=\"622f3ce2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6>\u201cDuring aging and in some cases of neurodegenerative diseases, including Huntington\u2019s disease and Parkinson\u2019s disease, the level of some of the gangliosides is lower in the patient\u2019s brain. We are interested in finding out why and developing a viable treatment that tackles the root of the disease, not just the symptoms.\u201d<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b018c4f elementor-widget elementor-widget-image\" data-id=\"2b018c4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/DSC_0115-edited-1024x768.jpg\" class=\"attachment-large size-large wp-image-12334\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/DSC_0115-edited-1024x768.jpg 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/DSC_0115-edited-e1616766352424-16x12.jpg 16w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Professor and GlycoNet Investigator Simonetta Sipione from the University of Alberta (Photo: GlycoNet)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6a472c58 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6a472c58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16613527 elementor-widget elementor-widget-text-editor\" data-id=\"16613527\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dr. Simonetta Sipione, GlycoNet Investigator and Professor in the Department of Pharmacology at the University of Alberta, was recently awarded a major five-year grant from the Canadian Institutes of Health Research (CIHR), worth $1.04 million. The project builds upon work previously funded by GlycoNet.<\/p>\n<p>The project aims to clarify the therapeutic role of gangliosides, a family of glycolipid molecules that have properties of both lipids and carbohydrates, in the brain.<\/p>\n<p>\u201cThese gangliosides are highly enriched in the healthy brain. They help brain cells communicate with each other and with the environment,\u201d says Sipione, lead Investigator on the project.<\/p>\n<p>\u201cDuring aging and in some cases of neurodegenerative diseases, including Huntington\u2019s disease and Parkinson\u2019s disease, the level of some of the gangliosides is lower in the patient\u2019s brain,\u201d says Sipione. \u201cWe are interested in finding out why and developing a viable treatment that tackles the root of the disease, not just the symptoms.\u201d<\/p>\n<p>Currently, patients who have neurodegenerative diseases are usually prescribed with medications to improve movement and fight depression. However, none of these medications address the disease cause, which is the accumulation of toxic proteins in the brain. Finding ways to prevent this toxic buildup will turn the table on current methods to treat these diseases.<\/p>\n<p>Previously, Sipione\u2019s team was able to slow down neurodegeneration in a mouse model of Huntington\u2019s disease through injection of a type of ganglioside called GM1 into the mouse brain.<\/p>\n<p>\u201cRestoring the level of GM1 in the brain could be a potential treatment for those who experience, or show signs of, neurodegeneration,\u201d says Sipione. Now, her team is investigating the mechanism of action, as this knowledge would shed light on other aspects in neuro- and glycoscience and help develop treatments.<\/p>\n<p>According to Sipione, the CIHR grant will enable her team to find out how GM1 helps the brain dispose of, or even prevent, the buildup of toxic proteins.<\/p>\n<p>\u201cTo use a simple analogy, toxic proteins are like garbage and your brain is like a house. If garbage accumulates in the house and no one throws it out, your house is going to smell. We think GM1 and other gangliosides have a key role in instructing brain cells so that the garbage (toxic proteins) can be thrown out properly and eliminated by trash collectors, which are other biomolecules in the brain,\u201d she adds. \u201cOur studies will help determine the underlying mechanism of GM1\u2019s therapeutic effects and whether other similar molecules could be a novel treatment, not only for Huntington\u2019s disease, but also potentially for Parkinson\u2019s and Alzheimer\u2019s disease.\u201d<\/p>\n<p>The Huntington Society of Canada reports that approximately 1 in 7,000 people in Canada has Huntington\u2019s disease. Another report from The Alzheimer\u2019s Society suggests that over 500,000 Canadians are living with dementia that results from neurogenerative disorders including Alzheimer\u2019s and Parkinson\u2019s disease. As seniors in Canada are a rapidly growing segment of the population, by 2031, it is estimated that the number will increase to 937,000.<\/p>\n<p>Sipione, who trained as a biochemist, believes that her laboratory\u2019s interdisciplinary approach provides a unique opportunity to uncover issues central to brain health. Her goal is to leverage knowledge from her research discoveries to create tangible benefits for people both in Canada and worldwide.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30598371 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"30598371\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6394a84a elementor-widget elementor-widget-text-editor\" data-id=\"6394a84a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5d57bc elementor-widget elementor-widget-spacer\" data-id=\"f5d57bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7e95a345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7e95a345\" data-element_type=\"section\" data-e-type=\"section\" 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d\u2019Emploi<\/a><\/span><br \/><span style=\"color: #ffffff;\">Ressources<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-17ef4216\" data-id=\"17ef4216\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7abe3bbd elementor-widget elementor-widget-text-editor\" data-id=\"7abe3bbd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\"><b>Nouvelles &amp; \u00c9v\u00e8nements<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/annual-reports\/\">Rapports Annuels<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/curioseity\/\">CuriOSEity<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\">Salle des m\u00e9dias<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\">Bulletins d\u2019information<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/symposium.canadianglycomics.ca\">Symposium Canadien sur la Glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/upcoming-events\/\">\u00c9v\u00e8nements \u00e0 Venir<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-4327fc8\" data-id=\"4327fc8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-31ac9f65 elementor-widget elementor-widget-text-editor\" data-id=\"31ac9f65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-7274ac47\" data-id=\"7274ac47\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-63c838b5 elementor-widget elementor-widget-image\" data-id=\"63c838b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b9eb864 elementor-widget elementor-widget-text-editor\" data-id=\"3b9eb864\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-45481b6b elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"45481b6b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70638400\" data-id=\"70638400\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1569f68c elementor-widget elementor-widget-text-editor\" data-id=\"1569f68c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Professor and GlycoNet Investigator Simonetta Sipione\u2019s research awarded major grant from the Canadian Institutes of Health Research<\/p>","protected":false},"author":2,"featured_media":12334,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-17172","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"Professor and GlycoNet Investigator Simonetta Sipione\u2019s research awarded 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