{"id":17381,"date":"2021-04-07T11:31:58","date_gmt":"2021-04-07T17:31:58","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=17381"},"modified":"2022-01-19T21:38:59","modified_gmt":"2022-01-20T04:38:59","slug":"glyconet-researchers-discover-how-a-plaque-fighting-protein-protects-against-alzheimers","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/glyconet-researchers-discover-how-a-plaque-fighting-protein-protects-against-alzheimers\/","title":{"rendered":"GlycoNet researchers discover how a plaque-fighting protein protects against Alzheimer\u2019s"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"17381\" class=\"elementor elementor-17381\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-57c7a73c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"57c7a73c\" data-element_type=\"section\" 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-11e3684b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"11e3684b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-344a3762\" data-id=\"344a3762\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5a1ff6ce elementor-widget elementor-widget-spacer\" data-id=\"5a1ff6ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71c0b502 elementor-widget elementor-widget-text-editor\" data-id=\"71c0b502\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">GlycoNet researchers discover how a plaque-fighting protein protects against Alzheimer\u2019s<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60ed80 elementor-widget elementor-widget-text-editor\" data-id=\"60ed80\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Katie Willis \u2022 Posted: April 7, 2021<\/span><\/p><p style=\"text-align: center;\">Research highlights potential pathway for new treatments for neurodegenerative diseases<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2134604b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2134604b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2e94df46\" data-id=\"2e94df46\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5154cd03 elementor-widget elementor-widget-text-editor\" data-id=\"5154cd03\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6>&#8220;Our ultimate goal is to translate this new information into a therapeutic treatment strategy. There are several different avenues to accomplish this, which we are pursuing with new funding our laboratory has received.\u201d\u00a0<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1bc21f71 elementor-widget elementor-widget-image\" data-id=\"1bc21f71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"682\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-1024x682.png\" class=\"attachment-large size-large wp-image-12495\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-1024x682.png 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-300x200.png 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-768x511.png 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png 1077w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Matthew Macauley led a research team that identified how one protein can protect against Alzheimer\u2019s disease\u2014a discovery that could point the way to new treatments for neurodegenerative diseases. (Photo: John Ulan)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ea10ded elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5ea10ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d3ab88e elementor-widget elementor-widget-text-editor\" data-id=\"5d3ab88e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>GlycoNet scientists at the University of Alberta have identified a mechanism for a protein that decreases the chance of developing Alzheimer\u2019s disease\u2014a discovery that highlights a new potential avenue for developing therapeutic treatments.<\/p><p>The protein, called CD33, is known for its connection to Alzheimer\u2019s disease susceptibility, but its exact role was unclear until now.\u00a0<\/p><p>There are two versions, or isoforms, of the CD33 protein: a long version that increases susceptibility to Alzheimer\u2019s disease and a short version that decreases the chance of getting the debilitating neurodegenerative disease.\u00a0<\/p><p>\u201cWe found that the short isoform has a completely different and opposite function from the long isoform,\u201d explained\u00a0<a href=\"https:\/\/www.ualberta.ca\/science\/about-us\/contact-us\/faculty-directory\/matthew-macauley\">Matthew Macauley<\/a>, assistant professor in the\u00a0<a href=\"https:\/\/www.ualberta.ca\/chemistry\">Department of Chemistry<\/a>\u00a0and Canada Research Chair in Chemical Glycoimmunology.\u00a0<\/p><p>\u201cThe short version of the CD33 protein makes immune cells in the brain, called microglia, better able to consume plaque-causing proteins, which contrasts to the long versions of CD33, which we previously showed represses this process.\u201d\u00a0<\/p><p>About 10 per cent of the population have a different version of the CD33 protein that causes them to make more of the short isoform of CD33\u2014which means that 90 per cent of people could benefit from a therapeutic intervention, Macauley explained.<\/p><p>\u201cOur ultimate goal is to translate this new information into a therapeutic treatment strategy,\u201d he explained. \u201cThere are several different avenues to accomplish this, which we are pursuing with new funding our laboratory has received.\u201d\u00a0<\/p><p>The new research builds on Macauley\u2019s\u00a0<a href=\"https:\/\/www.ualberta.ca\/folio\/2020\/10\/scientists-develop-new-tools-to-study-the-immune-system.html\">previous work<\/a>\u00a0studying the\u00a0<a href=\"https:\/\/www.ualberta.ca\/folio\/2019\/12\/how-a-protein-in-your-brain-could-protect-against-alzheimers-disease.html\">CD33 protein<\/a>.\u00a0<\/p><p>Co-authors on the study include research associate Abhishek Bhattacherjee and PhD student Jaesoo Jung in Macauley\u2019s lab, as well as\u00a0<a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/jrplemel\">Jason Plemel<\/a>, an assistant professor of medicine and neurology in the\u00a0<a href=\"https:\/\/www.ualberta.ca\/medicine\/index.html\">Faculty of Medicine &amp; Dentistry<\/a>\u00a0and member of the\u00a0<a href=\"https:\/\/www.ualberta.ca\/neuroscience-and-mental-health-institute\/index.html\">Neuroscience and Mental Health Institute<\/a>.<\/p><p>Funding for the research was provided by the\u00a0<a href=\"https:\/\/alzheimer.ca\/en?gclid=CjwKCAjw9MuCBhBUEiwAbDZ-7oPuQRd93oosyFxoZjs6_CKwxOSGXcDKRJkgKJlILRs3HURa_AO7rhoC3lYQAvD_BwE\">Alzheimer Society of Canada<\/a>, the\u00a0<a href=\"https:\/\/cihr-irsc.gc.ca\/e\/193.html\">Canadian Institutes of Health Research<\/a>\u00a0et \u00e0\u00a0<a href=\"https:\/\/canadianglycomics.ca\/fr\/\">GlycoNet<\/a>. Macauley is also an investigator with GlycoNet, a Canada-wide network of researchers based at the U of A who are working to further understanding of biological roles for sugars.<\/p><p>The study, \u201c<a href=\"https:\/\/molecularneurodegeneration.biomedcentral.com\/articles\/10.1186\/s13024-021-00443-6\">The CD33 short isoform is a gain-of-function variant that enhances Ab<sub>1-42<\/sub>\u00a0phagocytosis in microglia<\/a>,\u201d was published in\u00a0<em>Molecular Neurodegeneration<\/em>.<\/p><p>This article is republished from <a href=\"https:\/\/www.ualberta.ca\/folio\/2021\/04\/u-of-a-chemists-discover-how-a-plaque-fighting-protein-protects-against-alzheimers.html\">University of Alberta&#8217;s Folio<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e47cca7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2e47cca7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4be26201 elementor-widget elementor-widget-text-editor\" data-id=\"4be26201\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-175027ed elementor-widget elementor-widget-spacer\" data-id=\"175027ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div 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href=\"http:\/\/canadianglycomics.ca\/fr\/research\/projects\/\">Projets<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-1e746bea\" data-id=\"1e746bea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-57f602a0 elementor-widget elementor-widget-text-editor\" data-id=\"57f602a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/\"><b>Formation<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" 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href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\">Salle des m\u00e9dias<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\">Bulletins d\u2019information<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/symposium.canadianglycomics.ca\">Symposium Canadien sur la Glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/upcoming-events\/\">\u00c9v\u00e8nements \u00e0 Venir<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-21f59ba1\" data-id=\"21f59ba1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13675445 elementor-widget elementor-widget-text-editor\" data-id=\"13675445\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-660e9f69\" data-id=\"660e9f69\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1849fd1f elementor-widget elementor-widget-image\" data-id=\"1849fd1f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35579a9e elementor-widget elementor-widget-text-editor\" data-id=\"35579a9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4eb3e546 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4eb3e546\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-750268c9\" data-id=\"750268c9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1dd69d76 elementor-widget elementor-widget-text-editor\" data-id=\"1dd69d76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Research highlights potential pathway for new treatments for neurodegenerative diseases<\/p>","protected":false},"author":2,"featured_media":12495,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-17381","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"Research highlights potential pathway for new treatments for neurodegenerative diseases\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Canadian Glycomics Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/canadianglycomics.ca\/fr\/glyconet-researchers-discover-how-a-plaque-fighting-protein-protects-against-alzheimers\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.4\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_CA\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Canadian Glycomics Network - Improving the quality of life of Canadians through glycomics\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"GlycoNet researchers discover how a plaque-fighting protein protects against Alzheimer\u2019s - Canadian Glycomics Network\" \/>\n\t\t<meta property=\"og:description\" content=\"Research highlights potential pathway for new treatments for neurodegenerative diseases\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/canadianglycomics.ca\/fr\/glyconet-researchers-discover-how-a-plaque-fighting-protein-protects-against-alzheimers\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png\" \/>\n\t\t<meta property=\"og:image:width\" content=\"1077\" \/>\n\t\t<meta property=\"og:image:height\" content=\"717\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2021-04-07T17:31:58+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2022-01-20T04:38:59+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"GlycoNet researchers discover how a plaque-fighting protein protects against Alzheimer\u2019s - Canadian Glycomics Network\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Research highlights potential pathway for new treatments for neurodegenerative diseases\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/glyconet-researchers-discover-how-a-plaque-fighting-protein-protects-against-alzheimers\\\/#blogposting\",\"name\":\"GlycoNet researchers discover how a plaque-fighting protein protects against Alzheimer\\u2019s - Canadian Glycomics Network\",\"headline\":\"GlycoNet researchers discover how a plaque-fighting protein protects against Alzheimer\\u2019s\",\"author\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/author\\\/cgnadmin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/canadianglycomics.ca\\\/wp-content\\\/uploads\\\/Macauley.png\",\"width\":1077,\"height\":717,\"caption\":\"7. 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