{"id":17751,"date":"2021-05-19T08:40:45","date_gmt":"2021-05-19T14:40:45","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=17751"},"modified":"2021-05-19T08:40:47","modified_gmt":"2021-05-19T14:40:47","slug":"carbohydrate-cage-allows-precise-drug-delivery-to-inflammation-site-in-the-gastrointestinal-tract","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/carbohydrate-cage-allows-precise-drug-delivery-to-inflammation-site-in-the-gastrointestinal-tract\/","title":{"rendered":"Carbohydrate \u2018cage\u2019 allows precise drug delivery to inflammation site in the gastrointestinal tract"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"17751\" class=\"elementor elementor-17751\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-76d4aaef elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"76d4aaef\" 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-59c35ff3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"59c35ff3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40d69690\" data-id=\"40d69690\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a2c141d elementor-widget elementor-widget-spacer\" data-id=\"7a2c141d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-339e58ae elementor-widget elementor-widget-text-editor\" data-id=\"339e58ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">Carbohydrate \u2018cage\u2019 allows precise drug delivery to inflammation site in the gastrointestinal tract<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3be03a0f elementor-widget elementor-widget-text-editor\" data-id=\"3be03a0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Ali Chou \u2022 Posted: May 19, 2021<\/span><\/p><p style=\"text-align: center;\">A GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d9b9a0b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4d9b9a0b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-73bc62f7\" data-id=\"73bc62f7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75af9176 elementor-widget elementor-widget-text-editor\" data-id=\"75af9176\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6>\u201cWith this approach, we could use much less drug in the treatment. Because the drug is only released at the lower GI tract, it would avoid negative systemic effects.\u201d<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-636be1cf elementor-widget elementor-widget-image\" data-id=\"636be1cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-1024x683.jpg\" class=\"attachment-large size-large wp-image-17771\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-1024x683.jpg 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-300x200.jpg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-768x512.jpg 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-1536x1025.jpg 1536w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-2048x1366.jpg 2048w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01-16x12.jpg 16w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">GlycoNet Investigators Dr. Laura Sly (left) and Dr. Harry Brumer (right). (Photo: UBC, Michael Smith Laboratories)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a383846 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3a383846\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ea61f0c elementor-widget elementor-widget-text-editor\" data-id=\"7ea61f0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>More Canadians suffer from inflammatory bowel disease (IBD) than anywhere else in the world, yet current treatments often have debilitating side effects and are not always effective.<\/p><p>According to <a href=\"https:\/\/crohnsandcolitis.ca\/About-Us\/Resources-Publications\/Impact-of-IBD-Report\">Crohn\u2019s and Colitis Canada<\/a>, 1 in 140 Canadians lives with Crohn\u2019s or colitis, the two main forms of IBD. The disease inflames the lining of the gastrointestinal (GI) tract and disrupt the body\u2019s ability to digest food, absorb nutrition, and eliminate waste in a healthy matter. This can lead to severe abdominal pain, chronic diarrhea, and life-threatening complications.<\/p><p>GlycoNet researchers from the University of British Columbia, BC Children\u2019s Hospital, and Agriculture and Agri-Food Canada, are challenging the status quo as they develop a technology that they termed \u201cGlycoCage.\u201d This technology is aimed to improve the efficacy of IBD drugs by refining the method of drug delivery to patients.<\/p><p>\u201cIBD has a significant economic impact\u2014in billions of dollars,\u201d says Dr. Harry Brumer, Lead Investigator of the project and Professor at the University of British Columbia. \u201cHalf of this comes from the direct costs associated with IBD treatment, where no definitive cure exists. The other half comes from the loss of productivity in those afflicted with the disease.\u201d<\/p><p>As a chronic disease, treatments options are rough. \u201cFor patients who resort to biologics\u2014the last type of treatment when all others fail\u2014they need to take the infusion every six weeks, and every time the treatment takes at least half a day,\u201d says Dr. Laura Sly, Co-Investigator of the project and Associate Professor at the BC Children\u2019s Hospital. \u201cAnd some people still don\u2019t respond to the treatments.\u201d<\/p><h6><strong>Cage it or lose it<\/strong><\/h6><p>For other types of patients, IBD are often treated with orally administered anti-inflammatory drugs, but these can be absorbed by the stomach or small intestine before reaching the lower gastrointestinal (GI) tract\u2014where the drugs are supposed to be. This means in order to get a sufficient amount of drug to the target site, a higher initial dosage is needed to compensate its loss during the transit. In the case of steroid anti-inflammatory drugs, long-term systemic uptake could result in side effects like thinning bones, severe fatigue, or muscle weakness.<\/p><p>Brumer, a glycoscientist specializes in complex carbohydrates (e.g. dietary fibre) and gut microbiota, believes that a glycomics-based approach could ensure a minimum loss of the drug before it reaches its destination in the lower GI tract.<\/p><p>The technology involves \u201ccaging\u201d existing or new IBD drugs with carbohydrate molecules. Analogous to adding a lock and a cage to a pile of treasures, carbohydrate molecules (lock and cage) are chemically linked to the drug (treasure), protecting it from the premature uptake by the upper GI tract.<\/p><p>\u201cWith this approach, we could use much less drug in the treatment,\u201d says Sly. \u201cBecause the drug is only released at the lower GI tract, it would avoid negative systemic effects.\u201d<\/p><h6><strong>Unlocking the cage for targeted release<\/strong><\/h6><p>Choosing the right carbohydrate molecules for caging is important, as the cage must be unlocked only at the lower GI tract.<\/p><p>In a <a href=\"https:\/\/www.nature.com\/articles\/nature12907\">previous study published in Nature<\/a>, Brumer and his team identified a group of gut bacteria commonly found in global populations. These bacteria reside in the lower GI tract and they can chop specific carbohydrate molecules into pieces. This makes the bacteria excellent candidates as \u201ckeys\u201d to unlock the glycocage.<\/p><p>In other words, when the caged drug passes through the esophagus, stomach, and small intestine, the drug remains protected inside the glycocage. Upon meeting the group of bacteria in the large intestine, the chemically linked carbohydrate will be chopped off from the drug, thus opening the cage and enabling the drug to assume its job\u2014reducing inflammations at the site.<\/p><h6><strong>A network framework catalyzes technology development<\/strong><\/h6><p>The technology, supported by GlycoNet since 2016, has evolved from a proof-of-concept design to <em>in vitro<\/em> development, and now to <em>in vivo<\/em> testing.<\/p><p>\u201cWhat really helps accelerate the technology development is the collaborative efforts from our diverse team of chemists, microbiologists, and clinical scientists across different provinces,\u201d says Brumer.<\/p><p>From synthesizing and conjugating carbohydrate molecules to different IBD drugs to validating the effect of caged drugs in biochemical assays, and to testing their real-time therapeutic potential in animal models, the team had preliminary results that indicate the GlycoCage technology could increase the efficacy of IBD drug and reduce inflammation. Yet, there are still more to be tested.<\/p><p>\u201cWe are now expanding our tests to different animal inflammation models that mimic diseases like Crohn\u2019s and ulcerative colitis. We hope to establish a broad portfolio of glycocaged drugs to treat intestinal inflammation, and validate its potential for translation into human therapies,\u201d says Brumer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f8a0100 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1f8a0100\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a5284d1 elementor-widget elementor-widget-text-editor\" data-id=\"5a5284d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-367ae3cd elementor-widget elementor-widget-spacer\" data-id=\"367ae3cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7bc946b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7bc946b4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-41f2ba55\" data-id=\"41f2ba55\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3af8d9f3 elementor-widget elementor-widget-text-editor\" data-id=\"3af8d9f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/\"><b>\u00c0 propos<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/administration\/\">Administration<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/glyconets-corporate-policies\/\">Politiques d\u2019entreprise<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/governance\/\">Gouvernance<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/partners\/\">Partenaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/people\/\">Qui nous sommes<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/become-a-member\/\">Devenir Membre<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-721962b1\" data-id=\"721962b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e47b20d elementor-widget elementor-widget-text-editor\" data-id=\"e47b20d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/canadianglycomics.ca\/fr\/research\/\"><b>Recherche<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/glyco-backgrounder\/\">introduction \u00e0 la glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/call-for-proposals\/\">Appel \u00e0  propositions<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/core-services\/\">Services Centraux<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/projects\/\">Projets<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-f4ff677\" data-id=\"f4ff677\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3da273dc elementor-widget elementor-widget-text-editor\" data-id=\"3da273dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/\"><b>Formation<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/webinar-series\/\">S\u00e9rie de webinaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/trainee-association\/\">Association des Stagiaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/internships-exchanges-awards\/\">Stages, \u00c9changes &amp; Bourses<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/opportunities\/\">Opportunit\u00e9s d\u2019Emploi<\/a><\/span><br \/><span style=\"color: #ffffff;\">Ressources<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-57014929\" data-id=\"57014929\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-59676cea elementor-widget elementor-widget-text-editor\" data-id=\"59676cea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\"><b>Nouvelles &amp; \u00c9v\u00e8nements<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/annual-reports\/\">Rapports Annuels<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/curioseity\/\">CuriOSEity<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\">Salle des m\u00e9dias<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\">Bulletins d\u2019information<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/symposium.canadianglycomics.ca\">Symposium Canadien sur la Glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/upcoming-events\/\">\u00c9v\u00e8nements \u00e0 Venir<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-76a7003a\" data-id=\"76a7003a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7dfafc50 elementor-widget elementor-widget-text-editor\" data-id=\"7dfafc50\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6a339b5f\" data-id=\"6a339b5f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1bd743f0 elementor-widget elementor-widget-image\" data-id=\"1bd743f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b38aba1 elementor-widget elementor-widget-text-editor\" data-id=\"3b38aba1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32d15486 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32d15486\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7cf11169\" data-id=\"7cf11169\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-38b4d8a0 elementor-widget elementor-widget-text-editor\" data-id=\"38b4d8a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>A GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease<\/p>","protected":false},"author":2,"featured_media":17771,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-17751","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"A GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Canadian Glycomics Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/canadianglycomics.ca\/fr\/carbohydrate-cage-allows-precise-drug-delivery-to-inflammation-site-in-the-gastrointestinal-tract\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.4\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_CA\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Canadian Glycomics Network - Improving the quality of life of Canadians through glycomics\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Carbohydrate \u2018cage\u2019 allows precise drug delivery to inflammation site in the gastrointestinal tract - Canadian Glycomics Network\" \/>\n\t\t<meta property=\"og:description\" content=\"A GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/canadianglycomics.ca\/fr\/carbohydrate-cage-allows-precise-drug-delivery-to-inflammation-site-in-the-gastrointestinal-tract\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01.jpg\" \/>\n\t\t<meta property=\"og:image:width\" content=\"2109\" \/>\n\t\t<meta property=\"og:image:height\" content=\"1407\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2021-05-19T14:40:45+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2021-05-19T14:40:47+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Carbohydrate \u2018cage\u2019 allows precise drug delivery to inflammation site in the gastrointestinal tract - Canadian Glycomics Network\" \/>\n\t\t<meta name=\"twitter:description\" content=\"A GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/brumer-sly-featured-01.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/carbohydrate-cage-allows-precise-drug-delivery-to-inflammation-site-in-the-gastrointestinal-tract\\\/#blogposting\",\"name\":\"Carbohydrate \\u2018cage\\u2019 allows precise drug delivery to inflammation site in the gastrointestinal tract - Canadian Glycomics Network\",\"headline\":\"Carbohydrate \\u2018cage\\u2019 allows precise drug delivery to inflammation site in the gastrointestinal tract\",\"author\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/author\\\/cgnadmin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/canadianglycomics.ca\\\/wp-content\\\/uploads\\\/brumer-sly-featured-01.jpg\",\"width\":2109,\"height\":1407,\"caption\":\"4. 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