{"id":19558,"date":"2021-11-12T14:48:33","date_gmt":"2021-11-12T21:48:33","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=19558"},"modified":"2021-12-16T09:03:13","modified_gmt":"2021-12-16T16:03:13","slug":"sars-cov-2-uses-sugars-to-invade-human-cells-new-study-shows","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/sars-cov-2-uses-sugars-to-invade-human-cells-new-study-shows\/","title":{"rendered":"SARS-CoV-2 uses sugars to invade human cells, new study shows"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"19558\" class=\"elementor elementor-19558\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46373347 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46373347\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7cebb680 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7cebb680\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-17531394\" data-id=\"17531394\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-51aa473a elementor-widget elementor-widget-spacer\" data-id=\"51aa473a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b255c0a elementor-widget elementor-widget-text-editor\" data-id=\"5b255c0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 class=\"post-title\" style=\"text-align: center;\">SARS-CoV-2 uses sugars to invade human cells, new study shows<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16eb82cc elementor-widget elementor-widget-text-editor\" data-id=\"16eb82cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">\u00a0Posted: November 12, 2021<\/span><\/p><p style=\"text-align: center;\">Understanding the process could help scientists look out for new, more infectious variants, say GlycoNet researchers.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-74711a34 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"74711a34\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1dc808af\" data-id=\"1dc808af\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1d5471f0 elementor-widget elementor-widget-image\" data-id=\"1d5471f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"342\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640.jpg\" class=\"attachment-medium_large size-medium_large wp-image-19559\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640.jpg 640w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640-300x160.jpg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640-18x10.jpg 18w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-236d26af elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"236d26af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7167d236 elementor-widget elementor-widget-text-editor\" data-id=\"7167d236\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Sugars found on the surface of human cells influence COVID-19 infection, according to a University of Alberta-led <a href=\"https:\/\/www.nature.com\/articles\/s41589-021-00924-1\">study<\/a> that is one of the first to observe this relationship and suggests that cells in the brain might be particularly susceptible.<\/p><p>\u201cThe idea here is that the virus is leveraging or using the host glycans, or the host sugars, to gain access to the cells,\u201d said <a href=\"https:\/\/macauleylab.ca\/our-team\/\">Matthew Macauley<\/a>, professor in the Department of Chemistry and Canada Research Chair in Chemical Glycoimmunology. \u201cThis mode of action of viral entry is not unprecedented,\u201d he said. \u201cWhat is a surprise, though, is that it hadn\u2019t really been detected.\u201d<\/p><p>These sugars, known as glycans, are made of sialic acid and a class of biomolecules that are essential for cell structure, energy storage and system regulation.<\/p><p>Macauley explained that up to 50 per cent of all viruses that infect our cells, the most well known of which is influenza, bind to sugars on cell receptors to gain access and infect the cell.<\/p><p>\u201cThat\u2019s what all of our cells have on them, so why not exploit what\u2019s there \u2014 that\u2019s what viruses are good at,\u201d he said.<\/p><p>The study was initiated by <a href=\"https:\/\/klassengroup.ca\/\">John Klassen<\/a>, professor of chemistry in the Faculty of Science, whose lab developed the analytical tools to screen glycans. Specifically, Klassen and co-workers used a mass spectrometry technique, called catch-and-release, to study what sugars interact with the spike protein of SARS-CoV-2.<\/p><p>After that, Macauley and European collaborators started applying biological tools to see whether they could demonstrate a correlation between the viral proteins\u2019 ability to recognize these sugars and the role it plays in the infection process.<\/p><p>Macauley\u2019s lab initially ran experiments with a relatively harmless pseudovirus, incapable of replicating in the lab, armed with the spike protein of SARS-CoV-2. After obtaining promising results, professor Tom Hobman\u2019s laboratory in the Department of Cell Biology in the Faculty of Medicine &amp; Dentistry replicated findings on authentic SARS-CoV-2 under appropriate biosafety containment.<\/p><p>The researchers used chemical biology tools to modulate those sugars on the cell surface to study the ability for the viruses to get inside and infect cells.<\/p><p>Though researchers have shown that the virus\u2019s ability to infect a cell drops by between two and 10 times when the production of sugars on cell receptors is blocked, Macauley suggested the process is not fully understood enough for the immediate development of a therapy.<\/p><p>\u201cBecause SARS-CoV-2 is constantly evolving, a variant that evolves with more sugar-dependent infection would be quite concerning, but our knowledge enables us to keep a lookout for such a variant,\u201d he said.<\/p><p>The paper also proposes that the particular sugars the researchers were investigating \u2014 glycolipids, which are sugars attached to lipid (fat) \u2014 are found in the highest concentrations in an area where COVID-19 has been recently shown to infect: the brain.<\/p><p>Macauley said earlier this year, a number of studies showed that SARS-CoV-2 can find its way to the brain and infect cells of the nervous system, including neurons.<\/p><p>\u201cWe speculate that these sugar interactions could relate to what&#8217;s called a tissue tropism, which is the cells of the host that support viral infection and replication.\u201d<\/p><p>The results from the study support similar work by one of the paper\u2019s co-authors, <a href=\"http:\/\/www.cardiactransplantresearch.med.ualberta.ca\/lori.php\">Lori West<\/a>, Canada Research Chair in Cardiac Transplantation in the Faculty of Medicine &amp; Dentistry, who is trying to understand why people with blood type A are more susceptible to getting COVID-19 and are more susceptible to a more severe type of infection.<\/p><p>Now, with access to the variants of concern, Klassen said the team is exploring whether the variants all have similar sugar binding properties or whether these mutations are actually leading to changes in their ability to recognize specific structures.<\/p><div class=\"row\"><div class=\"col-12 col-sm\"><div class=\"story-content\"><p>Macauley, Klassen, and West are all network investigators with <a href=\"https:\/\/canadianglycomics.ca\/fr\/\">GlycoNet<\/a>, a pan-Canadian Network Centre of Excellence of more than 170 glycomics researchers, centred at the U of A.<\/p><\/div><\/div><\/div><p><em>This article is republished from <a href=\"https:\/\/www.ualberta.ca\/folio\/2021\/11\/sars-cov-2-uses-sugars-to-invade-human-cells-new-study-shows.html\">Folio<\/a>.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fa9fcd elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8fa9fcd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1abad270 elementor-widget elementor-widget-text-editor\" data-id=\"1abad270\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42214365 elementor-widget elementor-widget-spacer\" data-id=\"42214365\" data-element_type=\"widget\" data-e-type=\"widget\" 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elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2a4ac927 elementor-widget elementor-widget-text-editor\" data-id=\"2a4ac927\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/\"><b>\u00c0 propos<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/administration\/\">Administration<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/glyconets-corporate-policies\/\">Politiques d\u2019entreprise<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/governance\/\">Gouvernance<\/a><\/span><br 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elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46835aa1 elementor-widget elementor-widget-text-editor\" data-id=\"46835aa1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-1e63c261\" data-id=\"1e63c261\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f6a8ba2 elementor-widget elementor-widget-image\" data-id=\"7f6a8ba2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6756407b elementor-widget elementor-widget-text-editor\" data-id=\"6756407b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c4e2a1c elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c4e2a1c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-59e3cffb\" data-id=\"59e3cffb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e68b411 elementor-widget elementor-widget-text-editor\" data-id=\"2e68b411\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Understanding the process could help scientists look out for new, more infectious variants, say GlycoNet researchers.<\/p>","protected":false},"author":2,"featured_media":19559,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-19558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"Understanding the process could help scientists look out for new, more infectious variants, say GlycoNet researchers.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Canadian Glycomics Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/canadianglycomics.ca\/fr\/sars-cov-2-uses-sugars-to-invade-human-cells-new-study-shows\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.4\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_CA\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Canadian Glycomics Network - Improving the quality of life of Canadians through glycomics\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"SARS-CoV-2 uses sugars to invade human cells, new study shows - Canadian Glycomics Network\" \/>\n\t\t<meta property=\"og:description\" content=\"Understanding the process could help scientists look out for new, more infectious variants, say GlycoNet researchers.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/canadianglycomics.ca\/fr\/sars-cov-2-uses-sugars-to-invade-human-cells-new-study-shows\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640.jpg\" \/>\n\t\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t\t<meta property=\"og:image:height\" content=\"342\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2021-11-12T21:48:33+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2021-12-16T16:03:13+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"SARS-CoV-2 uses sugars to invade human cells, new study shows - Canadian Glycomics Network\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Understanding the process could help scientists look out for new, more infectious variants, say GlycoNet researchers.\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/virus-g989fd2987_640.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/sars-cov-2-uses-sugars-to-invade-human-cells-new-study-shows\\\/#blogposting\",\"name\":\"SARS-CoV-2 uses sugars to invade human cells, new study shows - Canadian Glycomics Network\",\"headline\":\"SARS-CoV-2 uses sugars to invade human cells, new study shows\",\"author\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/author\\\/cgnadmin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/canadianglycomics.ca\\\/wp-content\\\/uploads\\\/virus-g989fd2987_640.jpg\",\"width\":640,\"height\":342,\"caption\":\"1. 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