{"id":19826,"date":"2022-01-26T08:55:00","date_gmt":"2022-01-26T15:55:00","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=19826"},"modified":"2022-01-26T11:24:33","modified_gmt":"2022-01-26T18:24:33","slug":"making-strides-in-alzheimers-research","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/making-strides-in-alzheimers-research\/","title":{"rendered":"Making strides in Alzheimer&#8217;s research"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"19826\" class=\"elementor elementor-19826\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46e4b925 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46e4b925\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 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menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/research\/call-for-proposals\/\" class = \"uael-sub-menu-item\">Appel \u00e0  propositions<\/a><\/li>\n\t<li id=\"menu-item-23739\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/research\/research-activities-costs\/\" class = \"uael-sub-menu-item\">Eligibilit\u00e9 aux Activit\u00e9s de Recherche et aux Frais Associ\u00e9s.<\/a><\/li>\n\t<li id=\"menu-item-10688\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/research\/projects\/\" class = \"uael-sub-menu-item\">Projets<\/a><\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-19047\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children parent uael-has-submenu uael-creative-menu\"><div class=\"uael-has-submenu-container\"><a 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class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/\" class = \"uael-sub-menu-item\">Nouvelles<\/a><\/li>\n\t<li id=\"menu-item-10695\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/curioseity\/\" class = \"uael-sub-menu-item\">Le Blog CuriOSEity<\/a><\/li>\n\t<li id=\"menu-item-13365\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/training\/webinar-series\/\" class = \"uael-sub-menu-item\">S\u00e9rie de webinaires<\/a><\/li>\n\t<li id=\"menu-item-10694\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/annual-reports\/\" class = \"uael-sub-menu-item\">Rapports Annuels<\/a><\/li>\n\t<li id=\"menu-item-10697\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d9b21b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2da3de12 elementor-widget elementor-widget-text-editor\" data-id=\"2da3de12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">Making strides in Alzheimer\u2019s research<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Aalyssa Atley \u2022 Posted: January 26, 2022<\/span><\/p><p style=\"text-align: center;\">GlycoNet researchers have made exciting advances in understanding Alzheimer\u2019s disease and are developing a potential therapeutic strategy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c7e1f5a elementor-widget elementor-widget-image\" data-id=\"2c7e1f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Image-8_2-e1643216999908.png\" title=\"Microglial cell\" alt=\"confocal image of a microglia cell in homeostatic conditions\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Immune cells in the brain called microglia play a role in the formation of neurodegenerative plaques. The image shows a microglial cell in normal\/healthy conditions (in a mouse model).<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Over half a million Canadians are living with dementia, according to the <a href=\"https:\/\/alzheimer.ca\/en?gclid=CjwKCAjw9MuCBhBUEiwAbDZ-7oPuQRd93oosyFxoZjs6_CKwxOSGXcDKRJkgKJlILRs3HURa_AO7rhoC3lYQAvD_BwE\">Alzheimer Society of Canada<\/a>, but the physical, psychological, social, and economic impacts ripple far beyond that number, affecting caregivers, family, and society as a whole. The <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia#:~:text=Alzheimer's%20disease%20is%20the%20most,60%2D70%25%20of%20cases.\">World Health Organization<\/a> estimates that Alzheimer\u2019s disease accounts for 60\u201370 per cent of dementia cases, and a cure is not yet available. While Alzheimer\u2019s disease remains challenging to study due to its slow progression, GlycoNet researchers have been taking exciting steps towards developing a therapeutic treatment.<\/p><p>\u201cOne striking observation made in the last 5\u201310 years is that genetic factors that can influence your susceptibility to Alzheimer\u2019s disease converge on immune cells in the brain, called microglia,\u201d says <a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/macauley\">Matthew Macauley<\/a>, GlycoNet researcher and Canada Research Chair in Chemical Glycoimmunology at the <a href=\"https:\/\/www.ualberta.ca\/index.html\">Universit\u00e9 de l\u2019Alberta<\/a> (U of A).<\/p><p>In Alzheimer\u2019s disease, neurodegenerative plaques begin forming decades before manifestation of the disease, and it\u2019s at this early stage of disease progression that Macauley and his team are studying how microglia influence formation of these plaques.<\/p><p>\u201cNot only do the quality of microglia\u2014defined by a person\u2019s genetic make-up\u2014influence the tendency to develop plaques, but it also influences how the microglia respond to the plaques once they are developed,\u201d explains Macauley. \u201cIn the brain, as the plaques start to develop, the microglia try their best to contain them in different ways. But in the process of trying to do so, they can change and develop into versions that are better or worse in fighting the disease.\u201d<\/p><p>Macauley emphasizes how his team is fortunate to be able to collaborate with other investigators that have significant expertise in microglia. This has enabled the Macauley lab to begin\u00a0unravelling how a carbohydrate-binding receptor, called CD33, controls microglia and Alzheimer\u2019s disease susceptibility. One of these key collaborators is GlycoNet researcher and assistant professor\u00a0<a href=\"https:\/\/www.ualberta.ca\/medicine\/about\/people\/details.html?n=jason-plemel\">Jason Plemel<\/a>\u00a0at the U of A.\u00a0<a href=\"https:\/\/canadianglycomics.ca\/fr\/glyconet-researchers-discover-how-a-plaque-fighting-protein-protects-against-alzheimers\/\">Last year<\/a>, the research team discovered that a short version (isoform) of CD33, found in only about 10 per cent of people, decreases the chances of developing Alzheimer\u2019s disease. They determined decreased susceptibility may be due to improved function of the microglia. At the earlier stages of the disease, microglia can eat, or \u201cphagocytose,\u201d smaller fibres called fibrils that eventually go on to form plaques, suggesting that the protective variant of CD33 lessens disease susceptibility through making microglia more proficient in this ability.<\/p><p><strong>Finding the right carbohydrate to unlock immune cell function<\/strong><\/p><p>Studying how the short version of CD33 functions motivated Macauley and his team to investigate what the long version of CD33 is doing and, in particular, what carbohydrates it recognizes.<\/p><p>\u201cThe short version can&#8217;t bind to carbohydrates, but the long version can,\u201d says Macauley. \u201cThat&#8217;s a really important point, because it implies that maybe the carbohydrates themselves in the brain are related to the etiology of Alzheimer\u2019s disease.\u201d<\/p><p>Since joining U of A, the Macauley Lab has collaborated closely with GlycoNet researcher and U of A professor <a href=\"https:\/\/klassengroup.ca\/\">John Klassen<\/a> to address the question of what carbohydrates bind to the long version of CD33.<\/p><p>\u201cRecently, we made a big breakthrough, which is that CD33 can bind to carbohydrates that have a chemical modification called sulfation,\u201d says Macauley. \u201cWe are very excited by these findings because carbohydrate sulfation is important in the brain.\u201d<\/p><p>Sulfation is essentially a \u201cdecoration\u201d to the carbohydrate, like an ornament on a Christmas tree. \u201cThose decorations can make a really big impact for recognition by CD33,\u201d explains Macauley.<\/p><p>The research team\u2019s findings related to carbohydrate sulfation were recently <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34661385\/\">published in <em>ACS Chemical Biology<\/em><\/a>.<\/p><p><strong>Developing a potential therapeutic strategy<\/strong><\/p><p>Using their knowledge of CD33 as a carbohydrate-binding receptor and its ability to control microglia, Macauley and his team have been developing a strategy to target the long version of CD33. They synthesized a carbohydrate that binds specifically to CD33, and attached it on onto liposomes\u2014nanoparticles with a lipid bilayer that mimics cell membranes. These liposomes are safe, FDA-approved, and often used as drug delivery vehicles.<\/p><p>\u201cThe liposomes engage CD33 on microglia and cause CD33 to be transported inside the cell,\u201d explains Macauley. \u201cThis is a process called endocytosis and it\u2019s a natural process, so we are in a way just exploiting its natural function. Driving CD33 inside the cell means that it is no longer where it needs to be to control microglia and, hence, it changes the function of the microglia.\u201d<\/p><p>U of A assistant professor <a href=\"https:\/\/www.ualberta.ca\/medical-genetics\/about\/faculty\/anastassia-voronova.html\">Anastassia Voronova<\/a> has been a key collaborator on this research involving liposomes. The team\u2019s findings were recently <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34517042\/\">published in the <em>Journal of Controlled Release<\/em><\/a> last fall.<\/p><p><strong>Next steps<\/strong><\/p><p>\u201cOur initial proof-of-concept study provides the motivation for using this approach to make the microglia better at stopping the accumulation of plaques and, hence, slowing down Alzheimer\u2019s disease,\u201d says Macauley. \u201cThese studies are at early stages and our team is excited about their potential.\u201d<\/p><p>The research is funded by <a href=\"https:\/\/canadianglycomics.ca\/fr\/\">GlycoNet<\/a>, the <a href=\"https:\/\/alzheimer.ca\/en\">Alzheimer Society of Canada<\/a>, <a href=\"https:\/\/westonfoundation.ca\/\">Weston Family Foundation<\/a>, and the <a href=\"https:\/\/cihr-irsc.gc.ca\/e\/193.html\">Canadian Institutes of Health Research<\/a>.<\/p><p><em>January is <\/em><a href=\"https:\/\/alzheimer.ca\/ab\/en\/alzheimers_awareness_month_2022\"><em>Alzheimer\u2019s Awareness Month<\/em><\/a><em> in Canada, bringing awareness to the disease and supports available.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bf3619 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9bf3619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7590d33a elementor-widget elementor-widget-text-editor\" data-id=\"7590d33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256dce24 elementor-widget elementor-widget-spacer\" data-id=\"256dce24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-39e939e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39e939e3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-2af0ce8f\" data-id=\"2af0ce8f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5cfb2509 elementor-widget elementor-widget-text-editor\" data-id=\"5cfb2509\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/\"><b>\u00c0 propos<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/administration\/\">Administration<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/glyconets-corporate-policies\/\">Politiques d\u2019entreprise<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/governance\/\">Gouvernance<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/partners\/\">Partenaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/people\/\">Qui nous sommes<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/become-a-member\/\">Devenir Membre<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-1482b921\" data-id=\"1482b921\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73398db8 elementor-widget elementor-widget-text-editor\" data-id=\"73398db8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/canadianglycomics.ca\/fr\/research\/\"><b>Recherche<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/glyco-backgrounder\/\">introduction \u00e0 la glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/call-for-proposals\/\">Appel \u00e0  propositions<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/core-services\/\">Services Centraux<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/projects\/\">Projets<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-5a98b2c4\" data-id=\"5a98b2c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-635684d8 elementor-widget elementor-widget-text-editor\" data-id=\"635684d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/\"><b>Formation<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/webinar-series\/\">S\u00e9rie de webinaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/trainee-association\/\">Association des Stagiaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/internships-exchanges-awards\/\">Stages, \u00c9changes &amp; Bourses<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/opportunities\/\">Opportunit\u00e9s d\u2019Emploi<\/a><\/span><br \/><span style=\"color: #ffffff;\">Ressources<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-321fd875\" data-id=\"321fd875\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab3155c elementor-widget elementor-widget-text-editor\" data-id=\"ab3155c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\"><b>Nouvelles &amp; \u00c9v\u00e8nements<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/annual-reports\/\">Rapports Annuels<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/curioseity\/\">CuriOSEity<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\">Salle des m\u00e9dias<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\">Bulletins d\u2019information<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/symposium.canadianglycomics.ca\">Symposium Canadien sur la Glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/upcoming-events\/\">\u00c9v\u00e8nements \u00e0 Venir<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-21af05b1\" data-id=\"21af05b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6dddfb45 elementor-widget elementor-widget-text-editor\" data-id=\"6dddfb45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6e5cf3ea\" data-id=\"6e5cf3ea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74b25ded elementor-widget elementor-widget-image\" data-id=\"74b25ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3035c0 elementor-widget elementor-widget-text-editor\" data-id=\"2a3035c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-399df715 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"399df715\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5874a6a7\" data-id=\"5874a6a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37e618ee elementor-widget elementor-widget-text-editor\" data-id=\"37e618ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>GlycoNet researchers have made exciting advances in understanding Alzheimer\u2019s disease and are developing a potential therapeutic strategy.<\/p>","protected":false},"author":2,"featured_media":19827,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[208,7,209],"class_list":["post-19826","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-alzheimer","tag-glyconet","tag-neurodegenerative-disease","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"GlycoNet 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