{"id":20200,"date":"2022-04-05T13:18:00","date_gmt":"2022-04-05T19:18:00","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=20200"},"modified":"2022-04-05T14:25:32","modified_gmt":"2022-04-05T20:25:32","slug":"molecules-with-anti-inflammatory-restorative-properties-could-be-key-to-tackling-neurodegenerative-disease","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/molecules-with-anti-inflammatory-restorative-properties-could-be-key-to-tackling-neurodegenerative-disease\/","title":{"rendered":"Molecules with anti-inflammatory, restorative properties could be key to tackling neurodegenerative disease"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"20200\" class=\"elementor elementor-20200\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46e4b925 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46e4b925\" 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d9b21b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2da3de12 elementor-widget elementor-widget-text-editor\" data-id=\"2da3de12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">Molecules with anti-inflammatory, restorative properties could be key to tackling neurodegenerative disease<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Aalyssa Atley \u2022 Posted: April 5, 2022<\/span><\/p><p style=\"text-align: center;\">GlycoNet researchers at the University of Alberta are studying a group of molecules that could provide insight into treating and monitoring neurodegenerative diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c7e1f5a elementor-widget elementor-widget-image\" data-id=\"2c7e1f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1-768x512.png\" class=\"attachment-medium_large size-medium_large wp-image-19722\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1-768x512.png 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1-300x200.png 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1-1024x683.png 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1-18x12.png 18w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1.png 1200w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">GlycoNet researcher Simonetta Sipione is a professor at the University of Alberta. (Photo: GlycoNet)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>GlycoNet researchers have found that gangliosides, a family of molecules with carbohydrate and lipid properties, provide protective effects against neurodegenerative disease and could lead to development of a potential treatment. They are also investigating whether gangliosides could be valuable indicators, or biomarkers, of neurodegeneration.<\/p><p><a href=\"https:\/\/www.ualberta.ca\/pharmacology\/people\/faculty\/sipione-detail.html\">Simonetta Sipione<\/a>, a GlycoNet researcher and professor in the University of Alberta\u2019s Faculty of Medicine and Dentistry, has been leading research on the role of gangliosides in the brain, using cell and mouse models of Huntington\u2019s disease\u2014a rare genetic neurodegenerative disorder that shares characteristics with more common neurodegenerative diseases including Alzheimer\u2019s and Parkinson\u2019s.<\/p><p>Gangliosides are abundant in the brain and are important for brain health. When Sipione and her team discovered that the production of gangliosides was impaired in Huntington\u2019s disease, they wondered whether boosting ganglioside levels could stop neurodegeneration. The researchers increased the levels of a particular ganglioside called GM1 in the brains of Huntington\u2019s mice, and found GM1 was able to block neurodegeneration and restore normal behaviour.<\/p><p>\u201cWhen we gave GM1 to these mice, we were able to restore motor function to normal, reduce depression and anxiety, and improve cognition,\u201d says Sipione. \u201cWe were able to improve all disease symptoms.\u201d<\/p><p>In a <a href=\"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-021-02374-x\">paper recently published in the <em>Journal of Neuroinflammation<\/em><\/a>, Sipione and her team found that GM1 decreases inflammatory responses by the immune cells of the brain, called microglia. Meanwhile, a lower amount of gangliosides in microglia was associated with increased inflammatory response. This observation could mean that changes in gangliosides contribute to making microglia more or less prone to inflammation.<\/p><p>\u201cThis is important because brain inflammation, known as neuroinflammation, has been described as a contributor to disease progression in Huntington\u2019s disease,\u201d explains Sipione. \u201cNeuroinflammation also occurs in other diseases like Alzheimer\u2019s or Parkinson\u2019s disease.\u201d<\/p><p>Another protective mechanism the research team is studying is the ability of GM1 and other gangliosides to promote cellular secretion of toxic proteins that contribute to disease, packed into nanoparticles called extracellular vesicles. These extracellular vesicles play a role in cell communication and help regulate the immune system. Sipione suspects that GM1 and other gangliosides improve the packaging and disposal of toxic proteins as part of the brain\u2019s \u201ctrash collection\u201d process. Microglia can then eliminate, at least in part, these extracellular vesicles and the toxic proteins they carry.<\/p><p>In collaboration with GlycoNet researchers <a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/jsk3\">John Klassen<\/a> et \u00e0 <a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/macauley\">Matthew Macauley<\/a> at the U of A, Sipione is investigating the mechanisms of gangliosides to better understand their protective effects, which will inform the development of a possible treatment for Huntington\u2019s and potentially other neurodegenerative diseases.<\/p><p><strong>Potential biomarkers of neurodegenerative disease progression<\/strong><\/p><p>Working with Klassen and U of A neurologist <a href=\"https:\/\/www.ualberta.ca\/medicine\/about\/people\/details.html?n=oksana-suchowersky\">Oksana Suchowersky<\/a>, Sipione is looking at how the levels of gangliosides in cerebrospinal fluid (surrounding the brain and spinal cord) correlate with disease progression or the severity of symptoms.<\/p><p>Through a partnership with <a href=\"https:\/\/hdclarity.net\/\">HDClarity<\/a>, a cerebrospinal fluid collection initiative, the research team is analyzing human cerebrospinal fluid samples taken from both Huntington\u2019s disease patients and healthy individuals. Once the team compiles the data on the levels of gangliosides, they will use machine learning tools to establish whether there are specific correlations between the level of one or more gangliosides and disease severity.<\/p><p>\u201cThere are very few biomarkers of neurodegeneration and disease progression that are easy to measure in Huntington\u2019s disease patients,\u201d says Sipione. \u201cIf we find that the levels of gangliosides correlate with disease severity, then we could measure the levels of gangliosides to predict disease progression in patients, and to predict or evaluate the effectiveness of potential treatments in clinical trials.\u201d<\/p><p>The research has received funding from GlycoNet, <a href=\"https:\/\/cihr-irsc.gc.ca\/e\/20416.html\">Canadian Institutes of Health Research (CIHR)<\/a>, and the <a href=\"https:\/\/givetouhf.ca\/\">University Hospital Foundation<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bf3619 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9bf3619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7590d33a elementor-widget elementor-widget-text-editor\" data-id=\"7590d33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256dce24 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elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6dddfb45 elementor-widget elementor-widget-text-editor\" data-id=\"6dddfb45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6e5cf3ea\" data-id=\"6e5cf3ea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74b25ded elementor-widget elementor-widget-image\" data-id=\"74b25ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3035c0 elementor-widget elementor-widget-text-editor\" data-id=\"2a3035c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-399df715 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"399df715\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5874a6a7\" data-id=\"5874a6a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37e618ee elementor-widget elementor-widget-text-editor\" data-id=\"37e618ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>GlycoNet researchers are studying a group of molecules that could provide insight into treating and monitoring neurodegenerative diseases.<\/p>","protected":false},"author":2,"featured_media":19722,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[7,216,209],"class_list":["post-20200","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-glyconet","tag-huntingtons","tag-neurodegenerative-disease","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"GlycoNet researchers are studying a group of molecules that could provide insight into treating and monitoring neurodegenerative diseases.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Canadian Glycomics Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/canadianglycomics.ca\/fr\/molecules-with-anti-inflammatory-restorative-properties-could-be-key-to-tackling-neurodegenerative-disease\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.4\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_CA\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Canadian Glycomics Network - Improving the quality of life of Canadians through glycomics\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Molecules with anti-inflammatory, restorative properties could be key to tackling neurodegenerative disease - Canadian Glycomics Network\" \/>\n\t\t<meta property=\"og:description\" content=\"GlycoNet researchers are studying a group of molecules that could provide insight into treating and monitoring neurodegenerative diseases.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/canadianglycomics.ca\/fr\/molecules-with-anti-inflammatory-restorative-properties-could-be-key-to-tackling-neurodegenerative-disease\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1.png\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1.png\" \/>\n\t\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-04-05T19:18:00+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2022-04-05T20:25:32+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Molecules with anti-inflammatory, restorative properties could be key to tackling neurodegenerative disease - Canadian Glycomics Network\" \/>\n\t\t<meta name=\"twitter:description\" content=\"GlycoNet researchers are studying a group of molecules that could provide insight into treating and monitoring neurodegenerative diseases.\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Simonetta-1200x800-1.png\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/molecules-with-anti-inflammatory-restorative-properties-could-be-key-to-tackling-neurodegenerative-disease\\\/#blogposting\",\"name\":\"Molecules with anti-inflammatory, restorative properties could be key to tackling neurodegenerative disease - Canadian Glycomics Network\",\"headline\":\"Molecules with anti-inflammatory, restorative properties could be key to tackling neurodegenerative disease\",\"author\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/author\\\/cgnadmin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/canadianglycomics.ca\\\/wp-content\\\/uploads\\\/Simonetta-1200x800-1.png\",\"width\":1200,\"height\":800,\"caption\":\"3. 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