{"id":20461,"date":"2022-03-15T09:53:00","date_gmt":"2022-03-15T15:53:00","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=20461"},"modified":"2022-05-27T09:01:34","modified_gmt":"2022-05-27T15:01:34","slug":"new-research-reveals-clues-to-how-antibodies-get-fine-tuned-to-fight-infection","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/new-research-reveals-clues-to-how-antibodies-get-fine-tuned-to-fight-infection\/","title":{"rendered":"New research reveals clues to how antibodies get fine-tuned to fight infection"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"20461\" class=\"elementor elementor-20461\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46e4b925 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46e4b925\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div 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elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2da3de12 elementor-widget elementor-widget-text-editor\" data-id=\"2da3de12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">New research reveals clues to how antibodies get fine-tuned to fight infection<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Adrianna MacPherson \u2022 Posted: March 15, 2022<\/span><\/p><p>Scientists discover a cellular mechanism that may yield insights into improving vaccines and better understanding cancer and autoimmune diseases.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c7e1f5a elementor-widget elementor-widget-image\" data-id=\"2c7e1f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"511\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-768x511.png\" class=\"attachment-medium_large size-medium_large wp-image-12495\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-768x511.png 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-300x200.png 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley-1024x682.png 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png 1077w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Chemistry professor Matthew Macauley and his research team have shed new light on how our immune systems gradually tailor antibodies to work better against infectious diseases. (Photo: John Ulan)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Researchers at the University of Alberta have uncovered new information about a cellular mechanism in the immune system that provides a critical step toward better understanding how antibodies evolve and improve in the human body.<\/p>\n<p>The antibodies our immune system produces need fine-tuning to reach maximum effectiveness. When a vaccine or pathogen is first introduced into our bodies, antibodies produced against these agents help protect us \u2014 but need to be optimized, explained <a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/macauley\">Matthew Macauley<\/a>, associate professor in the <a href=\"https:\/\/www.ualberta.ca\/chemistry\/index.html\">Department of Chemistry<\/a>.<\/p>\n<p>\u201cSlowly, our immune system improves the ability of the antibody to recognize their target, and makes them better and better.\u201d<\/p>\n<p>In a process called antibody affinity maturation, antibodies become better by evolving to bind more tightly to their target. This process occurs through mutations in a pseudo-random fashion. Then, as Macauley explained, in a highly orchestrated series of events, mutations that improve antibodies\u2019 ability to recognize their target are selected.<\/p>\n<p><strong>Getting to the centre of how antibodies adapt<\/strong><\/p>\n<p>The complex process of selecting the best antibody happens in the germinal centre, in a process called the germinal centre reaction. If the goal is to be able to make vaccines even more effective and durable, scientists need to better understand this important location and the process of how they evolve, said PhD candidate <a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/enterina\">Jhon Enterina<\/a>, who was the first author on the study.<\/p>\n<p>One standard approach immunologists have used to study the germinal centre for the past 20 to 30 years has been to look at specific carbohydrates on the surface of the white blood cells in the germinal centre as an identifying marker. Macauley, whose research as a network investigator with the pan-Canadian research network GlycoNet focuses on carbohydrates, took notice of this.<\/p>\n<p>\u201cWe began asking ourselves, do these carbohydrates have a function? They\u2019re probably not just there for us to identify, they\u2019re likely serving an important role.\u201d<\/p>\n<p>B cells are the type of white blood cell that make antibodies. When B cells recognize a component of a vaccine or pathogen, it causes B cells to morph into more specialized germinal centre B cells. It is these specialized cells that have a unique set of carbohydrates on their surface. That\u2019s where Macauley saw an opportunity to get to the bottom of the process.<\/p>\n<p>\u201cAs the carbohydrates are changing in the germinal centre into a different type, we came up with a fairly simple way to test for their function: just stop them from changing and see what happens,\u201d he said.<\/p>\n<p>Macauley and his team created a specific model to prevent the changes from occurring. \u201cThis was accomplished at the genetic level. Normally an enzyme gets turned off in germinal centre B cells, so we simply didn\u2019t allow the cells to turn it off.\u201d<\/p>\n<p>In doing so, they found key information about the mechanisms taking place in the germinal centre.<\/p>\n<p>\u201cWe connected those changes to a protein receptor called CD22 that recognizes the key carbohydrates.\u201d<\/p>\n<p>The germinal centre is especially challenging to study because it can\u2019t readily be studied in a petri dish. Once germinal centre cells are taken outside of their natural environment in the body, they die within a few hours. Additionally, the cells within the germinal centre divide at the fastest rate of all mammalian cells, even faster than cancer cells.<\/p>\n<p>The reason these cells divide so rapidly is that it&#8217;s critical for our bodies to evolve antibodies as fast as possible to neutralize pathogens before it&#8217;s too late, said Macauley.<\/p>\n<p>Many diseases, such as cancer or autoimmune diseases, stem from the germinal centre getting out of control. However, before scientists are able to find out how to control this key area in the body, \u201cwe need to know what proper controls are in the first place, and are still a long ways from having all the answers,\u201d noted Macauley.<\/p>\n<p>\u201cIt\u2019s a very complex process. And despite all of the insights that have been made in the last 10 years, there are still many questions about the germinal centre, so this is providing another insight into one of the mechanisms that controls it.\u201d<\/p>\n<p>The research was supported by grants from the <a href=\"https:\/\/www.nih.gov\/\">National Institutes of Health<\/a> et le <a href=\"https:\/\/www.nserc-crsng.gc.ca\/index_eng.asp\">Natural Sciences and Engineering Research Council of Canada<\/a>, as well as a <a href=\"https:\/\/www.chairs-chaires.gc.ca\/home-accueil-eng.aspx\">Canada Research Chair<\/a> in Chemical Glycoimmunology to Macauley and a fellowship from the <a href=\"https:\/\/arthritis.ca\/\">Canadian Arthritis Society<\/a> and an <a href=\"https:\/\/albertainnovates.ca\/\">Alberta Innovates<\/a> graduate student scholarship to Enterina.<\/p>\n<p>The study, \u201c<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(22)00248-0\">Coordinated changes in glycosylation regulate the germinal centre through CD22<\/a>,\u201d was published in Cell Reports.<\/p>\n<p><em>This article is republished from <a href=\"https:\/\/www.ualberta.ca\/folio\/2022\/03\/new-research-reveals-clues-to-how-antibodies-get-fine-tuned-to-fight-infection.html\">Folio<\/a>.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bf3619 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9bf3619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7590d33a elementor-widget elementor-widget-text-editor\" data-id=\"7590d33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256dce24 elementor-widget elementor-widget-spacer\" data-id=\"256dce24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-39e939e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39e939e3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-2af0ce8f\" data-id=\"2af0ce8f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5cfb2509 elementor-widget elementor-widget-text-editor\" data-id=\"5cfb2509\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/\"><b>\u00c0 propos<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/administration\/\">Administration<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/glyconets-corporate-policies\/\">Politiques d\u2019entreprise<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/governance\/\">Gouvernance<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/partners\/\">Partenaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/people\/\">Qui nous sommes<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/about\/become-a-member\/\">Devenir Membre<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-1482b921\" data-id=\"1482b921\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73398db8 elementor-widget elementor-widget-text-editor\" data-id=\"73398db8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/canadianglycomics.ca\/fr\/research\/\"><b>Recherche<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/glyco-backgrounder\/\">introduction \u00e0 la glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/call-for-proposals\/\">Appel \u00e0  propositions<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/core-services\/\">Services Centraux<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/projects\/\">Projets<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-5a98b2c4\" data-id=\"5a98b2c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-635684d8 elementor-widget elementor-widget-text-editor\" data-id=\"635684d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/\"><b>Formation<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/webinar-series\/\">S\u00e9rie de webinaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/trainee-association\/\">Association des Stagiaires<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/internships-exchanges-awards\/\">Stages, \u00c9changes &amp; Bourses<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/training\/opportunities\/\">Opportunit\u00e9s d\u2019Emploi<\/a><\/span><br \/><span style=\"color: #ffffff;\">Ressources<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-321fd875\" data-id=\"321fd875\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab3155c elementor-widget elementor-widget-text-editor\" data-id=\"ab3155c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\"><b>Nouvelles &amp; \u00c9v\u00e8nements<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/annual-reports\/\">Rapports Annuels<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/curioseity\/\">CuriOSEity<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\">Salle des m\u00e9dias<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\">Bulletins d\u2019information<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/symposium.canadianglycomics.ca\">Symposium Canadien sur la Glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/upcoming-events\/\">\u00c9v\u00e8nements \u00e0 Venir<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-21af05b1\" data-id=\"21af05b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6dddfb45 elementor-widget elementor-widget-text-editor\" data-id=\"6dddfb45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6e5cf3ea\" data-id=\"6e5cf3ea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74b25ded elementor-widget elementor-widget-image\" data-id=\"74b25ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3035c0 elementor-widget elementor-widget-text-editor\" data-id=\"2a3035c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-399df715 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"399df715\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5874a6a7\" data-id=\"5874a6a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37e618ee elementor-widget elementor-widget-text-editor\" data-id=\"37e618ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Scientists discover a cellular mechanism that may yield insights into improving vaccines and better understanding cancer and autoimmune diseases.<\/p>","protected":false},"author":2,"featured_media":12495,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[217,7,218],"class_list":["post-20461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-antibodies","tag-glyconet","tag-infection","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"Scientists discover a cellular mechanism that may yield insights into improving vaccines and better understanding cancer and autoimmune diseases.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Canadian Glycomics Network\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/canadianglycomics.ca\/fr\/new-research-reveals-clues-to-how-antibodies-get-fine-tuned-to-fight-infection\/\" \/>\n\t\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.4\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_CA\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Canadian Glycomics Network - Improving the quality of life of Canadians through glycomics\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"New research reveals clues to how antibodies get fine-tuned to fight infection - Canadian Glycomics Network\" \/>\n\t\t<meta property=\"og:description\" content=\"Scientists discover a cellular mechanism that may yield insights into improving vaccines and better understanding cancer and autoimmune diseases.\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/canadianglycomics.ca\/fr\/new-research-reveals-clues-to-how-antibodies-get-fine-tuned-to-fight-infection\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png\" \/>\n\t\t<meta property=\"og:image:width\" content=\"1077\" \/>\n\t\t<meta property=\"og:image:height\" content=\"717\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-03-15T15:53:00+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2022-05-27T15:01:34+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:title\" content=\"New research reveals clues to how antibodies get fine-tuned to fight infection - Canadian Glycomics Network\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Scientists discover a cellular mechanism that may yield insights into improving vaccines and better understanding cancer and autoimmune diseases.\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Macauley.png\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/new-research-reveals-clues-to-how-antibodies-get-fine-tuned-to-fight-infection\\\/#blogposting\",\"name\":\"New research reveals clues to how antibodies get fine-tuned to fight infection - Canadian Glycomics Network\",\"headline\":\"New research reveals clues to how antibodies get fine-tuned to fight infection\",\"author\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/author\\\/cgnadmin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/canadianglycomics.ca\\\/fr\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/canadianglycomics.ca\\\/wp-content\\\/uploads\\\/Macauley.png\",\"width\":1077,\"height\":717,\"caption\":\"7. 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