{"id":20561,"date":"2022-06-20T22:28:28","date_gmt":"2022-06-21T04:28:28","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=20561"},"modified":"2022-06-20T22:34:19","modified_gmt":"2022-06-21T04:34:19","slug":"enzymes-linked-with-immune-cell-activity-could-hold-key-to-better-understanding-inflammation","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/enzymes-linked-with-immune-cell-activity-could-hold-key-to-better-understanding-inflammation\/","title":{"rendered":"Enzymes linked with immune cell activity could hold key to better understanding inflammation"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"20561\" class=\"elementor elementor-20561\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46e4b925 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46e4b925\" data-element_type=\"section\" 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elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2da3de12 elementor-widget elementor-widget-text-editor\" data-id=\"2da3de12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">Enzymes linked with immune cell activity could hold key to better understanding inflammation<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Adrianna MacPherson \u2022 Posted: June 20, 2022<\/span><\/p><p class=\"teaser\" style=\"text-align: center;\">Findings show promise for developing potential new anti-inflammatory drugs and treatments for autoimmune diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c7e1f5a elementor-widget elementor-widget-image\" data-id=\"2c7e1f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"433\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-768x433.jpeg\" class=\"attachment-medium_large size-medium_large wp-image-20563\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-768x433.jpeg 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-300x169.jpeg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-1024x577.jpeg 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-1536x865.jpeg 1536w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-2048x1154.jpeg 2048w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/220620-neu-chris-cairo-main-3000-px-18x10.jpeg 18w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Chris Cairo and his research team found that a group of enzymes called neuraminidases could offer clues to understanding inflammation and eventually finding new ways of treating it. (Photo: Richard Siemens)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>New research shows a group of enzymes may have a critical role in the process of how immune cells are activated and then migrate to certain sites in the body \u2014 findings that could improve our understanding of inflammation and potentially lead to new treatments.\u00a0<\/p><p>In a recent\u00a0<a href=\"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202101218R\">study<\/a>, researchers explored a particular family of enzymes called neuraminidases<em>.<\/em>\u00a0\u201cWe wanted to know whether these enzymes were involved in inflammation, whether they do anything important in the immune system,\u201d says\u00a0<a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/ccairo\">Chris Cairo<\/a>.\u00a0<\/p><p>Cairo and his team found that certain neuraminidase enzymes act as either pro-inflammatory or anti-inflammatory. They help to regulate the way the immune cells move and interact within the body.\u00a0<\/p><p>The findings show promise for developing potential inflammatory therapeutics, and could be useful in treating diseases, explains Cairo, a professor in the\u00a0<a href=\"https:\/\/www.ualberta.ca\/chemistry\/index.html\">Department of Chemistry<\/a>. For example, in an autoimmune disorder where too many immune cells are being recruited to a particular area, an enzyme with a subtly anti-inflammatory effect may help turn down the intensity of that immune response while not completely eradicating the person\u2019s immune system.<\/p><p>Neuraminidases cleave a specific carbohydrate residue from proteins and lipids in cells. Many important protein molecules in the immune system are glycosylated \u2014 meaning they have a carbohydrate attached to them \u2014 and these enzymes could influence specific interactions.<\/p><p>When immune cells move through the body, they search for something they recognize in the form of receptors or carbohydrates on the exterior of cells. If these receptors or the carbohydrate on them are modified in any way, the immune cell\u2019s ability to find and bind to those sites is compromised. When these enzymes cleave off the neuraminic acid on immune cells, the immune cells are activated in a different way, although researchers are still trying to refine their understanding of the process.<\/p><p>\u201cBiology doesn\u2019t do things for no reason. You don\u2019t have a whole family of enzymes that are just there by accident \u2014 they serve a role,\u201d says Cairo.<\/p><p>In the study, researchers looked at animal models missing specific neuraminidase enzymes. They found that this family of enzymes was unique in that some acted in an anti-inflammatory way, whereas others acted in a pro-inflammatory way.<\/p><p>\u201cAs an enzyme family they\u2019re both positive and negative regulators, which I think was not at all expected,\u201d says Cairo.<\/p><p>Cairo and his team took a broader approach, looking at the enzyme in a more general sense rather than examining a niche question or specific disease-related issue.\u00a0<\/p><p>\u201cWe have a better idea of what this is doing to the whole immune system rather than just what it\u2019s doing to one cell type or one protein,\u201d he says.<\/p><p>These neuraminidase enzymes aren\u2019t as well studied because they\u2019re challenging to work with, explains Cairo, but they hold a lot of promise.\u00a0<\/p><p>\u201cWe\u2019re probably coming across a whole enzyme system that could be very valuable in the future. But we\u2019ve got to understand the mechanisms much better.\u201d<\/p><p>The work was supported by a\u00a0<a href=\"https:\/\/canadianglycomics.ca\/fr\/\">GlycoNet<\/a>\u00a0student travel grant, GlycoNet collaborative team grants, and the\u00a0<a href=\"https:\/\/cihr-irsc.gc.ca\/e\/193.html\">Canadian Institutes of Health Research<\/a>.\u00a0<\/p><p><em>Republished from <a href=\"https:\/\/www.ualberta.ca\/folio\/2022\/06\/enzymes-linked-with-immune-cell-activity-could-hold-key-to-better-understanding-inflammation.html\">Folio<\/a>.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bf3619 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9bf3619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7590d33a elementor-widget elementor-widget-text-editor\" data-id=\"7590d33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256dce24 elementor-widget elementor-widget-spacer\" data-id=\"256dce24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div 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data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6e5cf3ea\" data-id=\"6e5cf3ea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74b25ded elementor-widget elementor-widget-image\" data-id=\"74b25ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3035c0 elementor-widget elementor-widget-text-editor\" data-id=\"2a3035c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-399df715 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"399df715\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5874a6a7\" data-id=\"5874a6a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37e618ee elementor-widget elementor-widget-text-editor\" data-id=\"37e618ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Findings show promise for developing potential new anti-inflammatory drugs and treatments for autoimmune diseases.<\/p>","protected":false},"author":2,"featured_media":20563,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[225,226,224,7,223],"class_list":["post-20561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-anti-inflammatory-drugs","tag-autoimmune-disease","tag-enzymes","tag-glyconet","tag-inflammation","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" 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