{"id":21759,"date":"2023-01-23T05:00:00","date_gmt":"2023-01-23T12:00:00","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=21759"},"modified":"2023-01-22T16:51:43","modified_gmt":"2023-01-22T23:51:43","slug":"redefining-compatibility-in-organ-transplantation","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/redefining-compatibility-in-organ-transplantation\/","title":{"rendered":"Redefining compatibility in organ transplantation"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"21759\" class=\"elementor elementor-21759\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46e4b925 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46e4b925\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column 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elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-58e5ff45\" data-id=\"58e5ff45\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-261d5238 uael-nav-menu__align-right uael-submenu-icon-classic uael-submenu-open-hover uael-submenu-animation-none uael-link-redirect-child uael-nav-menu__breakpoint-tablet uael-nav-menu-toggle-label-no elementor-widget elementor-widget-uael-nav-menu\" data-id=\"261d5238\" data-element_type=\"widget\" data-e-type=\"widget\" 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menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/research\/call-for-proposals\/\" class = \"uael-sub-menu-item\">Appel \u00e0  propositions<\/a><\/li>\n\t<li id=\"menu-item-23739\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/research\/research-activities-costs\/\" class = \"uael-sub-menu-item\">Eligibilit\u00e9 aux Activit\u00e9s de Recherche et aux Frais Associ\u00e9s.<\/a><\/li>\n\t<li id=\"menu-item-10688\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/research\/projects\/\" class = \"uael-sub-menu-item\">Projets<\/a><\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-19047\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children parent uael-has-submenu uael-creative-menu\"><div class=\"uael-has-submenu-container\"><a 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d9b21b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2da3de12 elementor-widget elementor-widget-text-editor\" data-id=\"2da3de12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">Redefining compatibility in organ transplantation<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Posted: January 23, 2023<\/span><\/p><p style=\"text-align: center;\">Applying a glycomics lens to the problem of organ donor-recipient compatibility, GlycoNet researcher Dr. Lori West is advancing the field of organ transplantation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c7e1f5a elementor-widget elementor-widget-image\" data-id=\"2c7e1f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"432\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/fotor_2023-1-22_16_23_43-768x432.jpg\" class=\"attachment-medium_large size-medium_large wp-image-21760\" alt=\"Dr. Lori West\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/fotor_2023-1-22_16_23_43-768x432.jpg 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/fotor_2023-1-22_16_23_43-300x169.jpg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/fotor_2023-1-22_16_23_43-1024x576.jpg 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/fotor_2023-1-22_16_23_43-18x10.jpg 18w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/fotor_2023-1-22_16_23_43.jpg 1200w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Dr. Lori West is a GlycoNet researcher and pediatric transplant cardiologist at the University of Alberta.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Approximately 4,100 Canadians are on the waitlist for a life-saving organ transplant. Sadly, each year hundreds of people die waiting for an available match<sup>1<\/sup>.<\/p><p>Dr. Lori West, a GlycoNet researcher and <a href=\"https:\/\/www.ualberta.ca\/medicine\/about\/people\/details.html?n=lori-west\">pediatric transplant cardiologist at the University of Alberta<\/a>, is one of the people working to change that statistic by improving organ donation rates and transplant patient care.<\/p><p>\u201cThe particular area of organ transplantation that brought me into the glycomics arena has to do with the ABO blood groups,\u201d said West. \u201cThe ABO blood groups are defined by the presence of certain glycans, or sugars, on the surfaces of cells and organs.\u201d<\/p><p>These specific sugars can influence whether a donated organ is accepted or rejected by a patient\u2019s immune system.<\/p><p>West\u2019s interest in ABO blood group sugars started out with looking for ways to improve heart transplantation in babies. A few decades ago, infants with major heart malformations had few options, but West\u2019s research changed that. She found that an infant&#8217;s immune system didn\u2019t have the same antibodies as an adult\u2019s and that it might not reject a transplanted organ based on blood group compatibility.<\/p><p>&#8220;The first baby to receive an intentional blood-group mismatched heart transplant in the world was on Valentine&#8217;s Day 1996, and it was completely successful,&#8221; said West.<\/p><p>\u201cNot only has this approach to ABO blood group mismatched transplants been adopted around the world now for babies, but the collaboration with carbohydrate chemists and people who understand glycomics has really had an impact on developing new questions\u2026that will allow us to understand the very basic biology of the ABO system in ways that haven\u2019t been possible before.\u201d<\/p><p>Without the need for blood-group compatibility, the donor pool could be expanded to match more patients with the organs they need to live. West continues to work towards this goal with support and collaborations through GlycoNet opening new doors to understanding how specific antibodies are directed against ABO blood groups.<\/p><p>For her leadership in the field of organ transplantation and her breakthrough research in infant heart transplantation, West was appointed as an Officer of the Order of Canada in 2020, but her investiture was delayed to last month due to the pandemic.<\/p><p>\u00a0<\/p><p><sup>1<\/sup><a href=\"https:\/\/organtissuedonation.ca\/en\/about\">Canadian Blood Services<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bf3619 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9bf3619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7590d33a elementor-widget elementor-widget-text-editor\" data-id=\"7590d33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256dce24 elementor-widget elementor-widget-spacer\" data-id=\"256dce24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div 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data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6e5cf3ea\" data-id=\"6e5cf3ea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74b25ded elementor-widget elementor-widget-image\" data-id=\"74b25ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3035c0 elementor-widget elementor-widget-text-editor\" data-id=\"2a3035c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-399df715 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"399df715\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5874a6a7\" data-id=\"5874a6a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37e618ee elementor-widget elementor-widget-text-editor\" data-id=\"37e618ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Applying a glycomics lens to the problem of organ donor-recipient compatibility, GlycoNet researcher Dr. Lori West is advancing the field of organ transplantation.<\/p>","protected":false},"author":2,"featured_media":21760,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[253,15,7,45,251,250],"class_list":["post-21759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-abo-blood-groups","tag-glycomics","tag-glyconet","tag-lori-west","tag-organ-transplantation","tag-transplantation","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in 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