{"id":22450,"date":"2023-07-04T21:06:48","date_gmt":"2023-07-05T03:06:48","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=22450"},"modified":"2024-09-14T10:28:44","modified_gmt":"2024-09-14T16:28:44","slug":"glyconet-researchers-develop-ice-inhibitors-to-protect-cells-during-cryopreservation","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/glyconet-researchers-develop-ice-inhibitors-to-protect-cells-during-cryopreservation\/","title":{"rendered":"GlycoNet researchers develop \u2018ice inhibitors\u2019 to protect cells during cryopreservation"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"22450\" class=\"elementor elementor-22450\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46e4b925 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46e4b925\" data-element_type=\"section\" 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menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/newsletters\/\" class = \"uael-sub-menu-item\">Bulletins d\u2019information<\/a><\/li>\n\t<li id=\"menu-item-11049\" class=\"menu-item menu-item-type-custom menu-item-object-custom uael-creative-menu\"><a href=\"http:\/\/www.symposium.canadianglycomics.ca\/\" class = \"uael-sub-menu-item\">Symposium Canadien sur la Glycomique<\/a><\/li>\n\t<li id=\"menu-item-10696\" class=\"menu-item menu-item-type-post_type menu-item-object-page uael-creative-menu\"><a href=\"https:\/\/canadianglycomics.ca\/fr\/news-events\/media-room\/\" class = \"uael-sub-menu-item\">Salle des m\u00e9dias<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul><\/nav>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d9b21b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2da3de12 elementor-widget elementor-widget-text-editor\" data-id=\"2da3de12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">GlycoNet researchers develop \u2018ice inhibitors\u2019 to protect cells during cryopreservation<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Geoff McMaster \u00b7 Posted: June 28, 2023<\/span><\/p><p style=\"text-align: center;\">New compounds could open more opportunities for vital medical treatments, organ and tissue transplants, and reproductive medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c7e1f5a elementor-widget elementor-widget-image\" data-id=\"2c7e1f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"494\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/jason_acker-rob_ben-768x494.jpg\" class=\"attachment-medium_large size-medium_large wp-image-22451\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/jason_acker-rob_ben-768x494.jpg 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/jason_acker-rob_ben-300x193.jpg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/jason_acker-rob_ben-1024x658.jpg 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/jason_acker-rob_ben-18x12.jpg 18w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/jason_acker-rob_ben.jpg 1400w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">(left to right) GlycoNet researchers Dr. Jason Acker, University of Alberta and Dr. Robert Ben, University of Ottawa<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The consensus among\u00a0<a href=\"https:\/\/apps.ualberta.ca\/directory\/person\/jacker\">Jason Acker<\/a>\u2019s research associates is that cryogenically preserving human organs for transplantation would be a scientific achievement on par with curing cancer, saving millions of lives each year.<\/p><p>And it may not be that far off, says the professor in the University of Alberta\u2019s\u00a0<a href=\"https:\/\/www.ualberta.ca\/laboratory-medicine-and-pathology\/index.html\">Department of Laboratory Medicine and Pathology<\/a>. Perhaps just five years away. In the meantime, a huge challenge has been freezing cell-based therapies without damaging the living cells.<\/p><p>Acker and University of Ottawa chemistry professor\u00a0<a href=\"https:\/\/www.uottawa.ca\/faculty-science\/professors\/robert-ben\">Robert Ben<\/a>\u00a0have figured out how to do just that. Through a spinoff company between the two universities, called\u00a0<a href=\"https:\/\/pantheracryo.com\/\">PanTHERA Cryosolutions<\/a>, they have engineered what\u2019s called ice recrystallization inhibitors \u2014 sugar-based molecules that prevent ice from forming around cells. They plan to release their product by the end of the year.<\/p><p>\u201cCells right now are the new medicines, whether for immune therapies or to treat cancer, and cryopreservation is the only way to store those for a long period of time,\u201d says Acker.<\/p><h3>Wide-ranging applications<\/h3><p>The potential applications for cryopreservation are wide-ranging, he adds, including medical treatments, organ and tissue preservation, reproductive medicine and agriculture.<\/p><p>Biological materials are normally preserved at -196 C \u2014 the temperature at which all molecular motion stops \u2014 to prevent ice crystals from accumulating around cells. But ice typically forms before cells reach that temperature after harvesting, or when temperature fluctuates during shipping and every time a freezer is opened to remove some of the biomaterial.<\/p><p>Think of ice cream left in your household freezer for a year, says Acker. Open the lid and it\u2019s coated with crunchy ice crystals.<\/p><p>PanTHERA has developed families of small, non-toxic synthetic carbohydrates that stop the accumulation of ice. The researchers aren\u2019t entirely certain why the compounds work as well as they do, but suspect that they penetrate a \u201cquasi-liquid layer\u201d found on the surface of ice crystals, disrupting the process by which water molecules add to their growth.<\/p><p>The compounds also mean biomaterials can be frozen at much higher temperatures. Since most standard, lab-based freezers cool to about -80 C, cryopreservation becomes more economically feasible.<\/p><p>To help take their new product to market and distribute it globally, PanTHERA has partnered with\u00a0<a href=\"https:\/\/www.biolifesolutions.com\/\">Biolife Solutions<\/a>\u00a0in Seattle, the world\u2019s largest manufacturer of cryopreservation solutions for cell and gene therapy.<\/p><h3>Inspired by nature<\/h3><p>Acker and Ben took their inspiration from natural organisms that can survive freezing. Fish, frogs and even trees have evolved to prevent ice forming in their bodily fluids, says Acker.<\/p><p>\u201cThat&#8217;s really the key part of our technology \u2014 we took the same structures,\u201d he says, adding that his research team screened almost 4,000 synthetic molecules over 10 years for their ability to control ice.<\/p><p>But the roots of Acker\u2019s research go much further back, as far as the U of A\u2019s renowned\u00a0<a href=\"https:\/\/www.ualberta.ca\/folio\/2022\/05\/sweet-success-worlds-largest-islet-transplant-program-celebrates-20-years.html\">Edmonton Protocol team<\/a>\u00a0and their need to cryopreserve islet cells. The U of A has since become a global centre of excellence for cryopreservation and cryobiology, with researchers across the faculties of medicine, engineering and science exploring new ways of preserving cells, tissues and organs.<\/p><p>There are only two universities, the other in the U.K., that have formal graduate programs in biopreservation at the master\u2019s and PhD levels, says Acker.<\/p><p>\u201cWe&#8217;re training the next generation of cryobiologists, who are fast becoming a hot commodity. Most of my graduate students are usually recruited into the cell and gene therapy space before they finish their degrees \u2014 the need is that desperate.\u201d<\/p><p>PanTHERA has received research support from the\u00a0<a href=\"https:\/\/cihr-irsc.gc.ca\/e\/193.html\">Canadian Institutes of Health Research<\/a>,\u00a0<a href=\"https:\/\/www.innovation.ca\/apply-manage-awards\/funding-opportunities\/major-science-initiatives-fund\">le Fonds des initiatives scientifiques majeures<\/a>,\u00a0<a href=\"https:\/\/cdtrp.ca\/en\/\">The Canadian Donation and Transplantation Research Program<\/a>,\u00a0<a href=\"https:\/\/hirsch-foundation.org\/en\">Hirsch Foundation<\/a>,\u00a0<a href=\"https:\/\/canadianglycomics.ca\/fr\/\">GlycoNet<\/a>,\u00a0<a href=\"https:\/\/greencentrecanada.com\/\">GreenCentre Canada<\/a>,\u00a0<a href=\"https:\/\/www.blood.ca\/\">Canadian Blood Services<\/a>,\u00a0<a href=\"https:\/\/creativedestructionlab.com\/\">Creative Destruction Lab<\/a>,\u00a0<a href=\"https:\/\/www.investottawa.ca\/\">Invest Ottawa<\/a>\u00a0et le\u00a0<a href=\"https:\/\/pantheracryo.com\/panthera-cryosolutions-receives-funding-to-support-research-and-development-project\/\">National Research Council of Canada Industrial Research Assistance Program<\/a>.\u00a0<\/p><p>Acker also received $40,000 from\u00a0<a href=\"https:\/\/albertainnovates.ca\/\">Alberta Innovates<\/a>\u00a0to study zebrafish as a model system for medical research and other applications in agriculture. His CIHR funding will help him further investigate the cryopreservation of tissues and organs. He has also worked with the Smithsonian Institute\u2019s\u00a0<a href=\"https:\/\/nationalzoo.si.edu\/center-for-species-survival\">Centre for Species Survival<\/a>\u00a0to look at how cryopreserving reproductive material from endangered species could help the centre\u2019s new species survival plan.<\/p><p>For cryobiology and cryopreservation research, there couldn\u2019t be a better time to be in this field, says Acker.<\/p><p>\u201cFive years ago, the idea of freezing an organ was still science fiction. Now with our partners at\u00a0<a href=\"https:\/\/www.massgeneral.org\/obgyn\/fertility\/treatments-and-services\/cryopreservation-program\">Massachusetts General Hospital<\/a>, we have demonstrated partial freezing of liver and lungs from humans and animals.<\/p><p>\u201cIt&#8217;s not the end goal, but it demonstrates that the technology we&#8217;re developing is leading us down that path.\u201d<\/p><p>\u00a0<\/p><p><em>Republished from <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ualberta.ca\/folio\/2023\/06\/researchers-develop-ice-inhibitors-to-protect-cells-during-cryopreservation.html\">Folio<\/a><\/span><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01a9760 elementor-widget elementor-widget-spacer\" data-id=\"01a9760\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div 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data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73398db8 elementor-widget elementor-widget-text-editor\" data-id=\"73398db8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/canadianglycomics.ca\/fr\/research\/\"><b>Recherche<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/glyco-backgrounder\/\">introduction \u00e0 la glycomique<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/call-for-proposals\/\">Appel \u00e0  propositions<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/core-services\/\">Services Centraux<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/research\/projects\/\">Projets<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-5a98b2c4\" data-id=\"5a98b2c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-635684d8 elementor-widget elementor-widget-text-editor\" data-id=\"635684d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" 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elementor-col-16 elementor-top-column elementor-element elementor-element-321fd875\" data-id=\"321fd875\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab3155c elementor-widget elementor-widget-text-editor\" data-id=\"ab3155c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\"><b>Nouvelles &amp; \u00c9v\u00e8nements<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/annual-reports\/\">Rapports Annuels<\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" 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data-id=\"21af05b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6dddfb45 elementor-widget elementor-widget-text-editor\" data-id=\"6dddfb45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-6e5cf3ea\" data-id=\"6e5cf3ea\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74b25ded elementor-widget elementor-widget-image\" data-id=\"74b25ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a3035c0 elementor-widget elementor-widget-text-editor\" data-id=\"2a3035c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-399df715 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"399df715\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5874a6a7\" data-id=\"5874a6a7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-37e618ee elementor-widget elementor-widget-text-editor\" data-id=\"37e618ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>New compounds could open more opportunities for vital medical treatments, organ and tissue transplants, and reproductive medicine.<\/p>","protected":false},"author":2,"featured_media":22451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"news-template","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[262,15,7,251,250],"class_list":["post-22450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-cryopreservation","tag-glycomics","tag-glyconet","tag-organ-transplantation","tag-transplantation","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta 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