{"id":25755,"date":"2024-12-13T10:03:27","date_gmt":"2024-12-13T17:03:27","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=25755"},"modified":"2024-12-13T10:03:30","modified_gmt":"2024-12-13T17:03:30","slug":"researchers-devise-a-quicker-more-efficient-way-to-make-life-saving-molecules","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/researchers-devise-a-quicker-more-efficient-way-to-make-life-saving-molecules\/","title":{"rendered":"Researchers devise a quicker, more efficient way to make life-saving molecules"},"content":{"rendered":"
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GlycoNet researcher leads development of a quicker, more efficient way to make life-saving molecules<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Improved method for creating nucleoside analogues opens the door to discovering countless treatments for everything from cancer to viral diseases.<\/p>

By Adrianna MacPherson\u00a0 \u2022\u00a0 Posted: 4 December,\u00a0 2024<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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(From left) U of A researchers Jason Wang, Thirupathi Nuligonda, Gautam Kumar, Dinithi Rajapaksha and Michael Meanwell found a new, more efficient way to make nucleoside analogues \u2014 a type of molecule that can be used in a wide range of treatments for everything from cancer to viral diseases. (Photo: Supplied)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A team of researchers has found a quicker and more efficient way to create nucleoside analogues, a type of small molecule that can be used in treatments for everything from cancer to viral diseases.<\/p>

\u201cNucleoside analogues are among the most important molecules to the advancement of modern medicine,\u201d says GlycoNet investigator Michael Meanwell<\/a>, who is also the Manley and Marian Johnston Professor in the Department of Chemistry<\/a> at the University of Alberta and corresponding author of a paper published in\u00a0Nature Communications<\/em>\u00a0describing the new process<\/a>.\u00a0<\/p>

\u201cThey\u2019re used as antivirals, as cancer therapeutics, in gene therapy. The first two drugs brought to market for treating COVID-19 were both nucleoside analogues.\u201d<\/p>

Meanwell and his team focused their approach on C4 modified nucleoside analogues, a particular subclass of these molecules. A few antiviral drugs within this subclass are already in clinical trials, highlighting their potential. But the issue is that \u201cthese types of nucleosides have been notoriously hard to make,\u201d Meanwell explains.<\/p>

\u201cPart of it has to do with the chemistry used to make them \u2014 it\u2019s mostly based on chemistry from 50, 60 years ago, and the advancements in modern organic chemistry have not yet been fully translated to this field of research.\u201d<\/p>

Until now, the most common ways to make these modified nucleoside analogues required a process taking anywhere from nine to 16 steps. The new approach requires just five steps.\u00a0<\/p>

Additionally, existing methods were all non-modular, meaning that making different analogues required designing entirely different routes. It would take a month or more to create just one molecular compound in this way. The new process is modular, so multiple analogues can be made at the same time \u2014 an advantage for researchers experimenting with different potential therapeutics.\u00a0<\/p>

\u201cBy streamlining the process, the barrier now is so much lower to doing drug discovery especially for academic labs working in this area,\u201d says Meanwell. \u201cYou can make all the different analogues you want, the chemistry is so much easier, and it reduces the amount of time needed.\u201d<\/p>

\u201cThe breadth of molecules we can make with this one process is truly unprecedented,\u201d he adds.<\/p>

Nucleosides are fundamental building blocks of DNA, and nucleoside analogues are simply modifications of those structures, explains Meanwell. \u201cThey inhibit the same processes associated with cell growth and cell replication that cancer cells and viral diseases take advantage of \u2014 by inhibiting them, you can treat those diseases.\u201d<\/p>

Over the past few decades, nucleoside analogues have been used in treatments for AIDS, Ebola, respiratory syncytial virus (RSV), hepatitis, and many more diseases and infections. A more efficient and effective way to manufacture these powerhouse molecules could pave the way for countless new therapeutics for a vast range of health conditions.\u00a0<\/p>

\u201cIt sounds like hyperbole, but they can treat such a broad range of diseases,\u201d says Meanwell. \u201cThey really stretch across so many different areas of health.\u201d<\/p>

\u201cC4 modified nucleoside analogues are so important medicinally because of the wide range of disease pathologies they can intercept,\u201d says lead author\u00a0Thirupathi Nuligonda<\/a>. \u201cNow, we have a modular approach to synthesize this important class of nucleoside.\u201d\u00a0<\/p>

The research was funded by\u00a0Striving for Pandemic Preparedness \u2014 The Alberta Research Consortium<\/a>.\u00a0<\/p><\/div>

Reposted from\u00a0Folio<\/a><\/em><\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Plus de nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Improved method for creating nucleoside analogues opens the door to discovering countless treatments for everything from cancer to viral diseases. <\/p>","protected":false},"author":8,"featured_media":25757,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[238,309,7,308,100,101],"class_list":["post-25755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-cancer","tag-drug-development","tag-glyconet","tag-michael-meanwell","tag-therapeutics","tag-university-of-alberta","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t