{"id":26533,"date":"2025-05-01T12:15:00","date_gmt":"2025-05-01T18:15:00","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=26533"},"modified":"2025-05-01T12:05:59","modified_gmt":"2025-05-01T18:05:59","slug":"a-digestive-treasure-chest-shows-promise-for-targeted-drug-treatment-in-the-gut","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/a-digestive-treasure-chest-shows-promise-for-targeted-drug-treatment-in-the-gut\/","title":{"rendered":"A digestive ‘treasure chest’ shows promise for targeted drug treatment in the gut"},"content":{"rendered":"
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A digestive \u2018treasure chest\u2019 shows promise for targeted drug treatment in the gut<\/h1>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease.<\/p>

\u00a0Posted: 1 May, 2025<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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UBC researchers Dr. Changqing Wang and Maggie (Wei Jen) Ma (Credit: Alex Walls)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments.<\/p>\n

The proof-of-concept study, published today in Science<\/em><\/a>, introduced a mechanism called \u2018GlycoCaging,\u2019  which uses specialized carbohydrates to shield drugs until they reach the lower gut. This targeted delivery system enhances therapeutic precision and enables the use of doses up to 10 times lower than current therapies.<\/p>\n

\u201cWith this technique, we have the ability to deliver not just steroids, but a range of drugs including anti-microbial compounds directly to the gut, potentially helping people with inflammatory bowel disease, gut infections and more,\u201d said co-senior author Dr. Harry Brumer, a GlycoNet investigator and professor in the UBC department of chemistry and Michael Smith Laboratories (MSL).<\/p>\n

An estimated 322,600 Canadians have inflammatory bowel disease (IBD) as of 2023 and Canada has one of the highest incidence rates in the world, according to Crohn\u2019s and Colitis Canada<\/a>.<\/p>\n

\u201cIt\u2019s a growing problem, and there\u2019s no known cure. It can be completely debilitating and it hits people in the prime of their life, between 19 and 29 years of age,\u201d said co-senior author Dr. Laura Sly, GlycoNet investigator and professor in the UBC department of pediatrics.<\/p>\n

Targeted drug delivery<\/strong><\/h2>\n

One of the treatments for IBD is anti-inflammatory steroids, often taken orally or intravenously. These have serious side effects including osteoporosis, high blood pressure, diabetes and negative mental health outcomes. They are used to treat flares for children, adults, and the roughly 30 per cent of adults for whom treatment with other medication doesn\u2019t work. <\/p>\n

Much of the medicine is absorbed in the stomach and upper intestine before reaching the inflamed gut area, so doctors administer the potent drugs in high doses to ensure an effective amount reaches the affected areas.<\/p>\n

GlycoCaging is a chemical process inspired by the UBC researchers\u2019 realization that certain carbohydrate molecules found in fruit and vegetable fiber can only be digested by bacteria that resides in our gut.<\/p>\n

The team bonded the molecule to a steroid, creating a \u2018treasure chest\u2019 for which the \u2018key\u2019 is a specific gut bacteria. They used a steroid not usual for IBD treatment to demonstrate GlycoCaging\u2019s potential to repurpose potent drugs.<\/p>\n

Significantly lower doses of potent drugs<\/strong><\/h2>\n

Using this mechanism, the researchers treated two types of mice that had IBD for up to nine weeks. Their GlycoCaged doses were three to 10 times lower than non-caged doses but had the same anti-inflammatory effects. The drug turned up in lower levels in the rest of the body than the non-caged version. In one group, inflammation in other areas of the body was not reduced, meaning the drug indeed affected only the gut. <\/p>\n

\u201cWe showed that this technique can be used on other steroids, including those commonly used in IBD treatment, as well as other anti-inflammatory drugs used in high doses with negative side effects,\u201d said Dr. Changqing Wang, research associate in UBC department of chemistry and MSL. <\/p>\n

Human potential<\/strong><\/h2>\n

To test the potential for treatment in humans, the research team checked to see if the bacteria upon which GlycoCaging relies existed in the gut of those with IBD.<\/p>\n

They looked for bacterial activity in fecal samples from 33 people, with and without IBD, and at a global database for genetic markers.  \u201cWe found that all people in the fecal sample study had the ability to activate the drugs, including people with IBD whether they are in remission or have active inflammation,\u201d said Maggie (Wei Jen) Ma, a doctoral student in UBC\u2019s experimental medicine program and BC Children\u2019s Hospital Research Institute. \u201cAnd, the majority of people had genetic markers indicating the ability to use the GlycoCage system.\u201d<\/p>\n

The research team has patented the technology and will now source funding for more advanced animal trials and human clinical trials.<\/p>\n

\u201cSustained funding from GlycoNet, from an initial Catalyst Grant through successive Collaborative Team Grants, has been essential in realizing the full proof-of-concept and potential of our approach,\u201d said Dr. Brumer. \u201cWe are especially grateful to members of the GlycoNet Administration, Research Management Committee, and Commercialization Committee for their continued support.\u201d<\/p>\n

(Adapted from UBC\u2019s press release<\/a><\/em>)<\/em><\/p>\n<\/div>\n

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Plus de nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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GlycoCage technology developed by GlycoNet researchers aims to improve current treatments for inflammatory bowel disease.<\/p>","protected":false},"author":8,"featured_media":26535,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[338,343,15,7,114,342,341,339,340],"class_list":["post-26533","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","tag-changqing-wang","tag-drug-discovery","tag-glycomics","tag-glyconet","tag-glycoscience","tag-ibd","tag-inflammatory-bowel-disease","tag-maggie-wei-jen-ma","tag-university-of-british-columbia","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t