{"id":27718,"date":"2025-10-08T17:13:55","date_gmt":"2025-10-08T23:13:55","guid":{"rendered":"https:\/\/canadianglycomics.ca\/?p=27718"},"modified":"2025-10-08T17:24:23","modified_gmt":"2025-10-08T23:24:23","slug":"glyconet-startup-avivo-achieves-worlds-first-blood-type-a-to-o-kidney-transplant-a-breakthrough-towards-universal-donor-organs","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/glyconet-startup-avivo-achieves-worlds-first-blood-type-a-to-o-kidney-transplant-a-breakthrough-towards-universal-donor-organs\/","title":{"rendered":"GlycoNet startup Avivo achieves world\u2019s first blood type A-to-O kidney transplant, a breakthrough for universal donor organs"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"27718\" class=\"elementor elementor-27718\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1d9b21b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1d9b21b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60ab717c\" data-id=\"60ab717c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27093231 elementor-widget elementor-widget-spacer\" data-id=\"27093231\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a31ce0 elementor-widget elementor-widget-page-title\" data-id=\"9a31ce0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;align&quot;:&quot;center&quot;}\" data-widget_type=\"page-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\n\t\t<div class=\"hfe-page-title hfe-page-title-wrapper elementor-widget-heading\">\n\n\t\t\t\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\n\t\t\t\t\t\t\t\t\n\t\t\t\tGlycoNet startup Avivo achieves world\u2019s first blood type A-to-O kidney transplant, a breakthrough for universal donor organs  \n\t\t\t<\/h1> \n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-516d26b9 elementor-widget elementor-widget-text-editor\" data-id=\"516d26b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><i>The successful transplant marks major progress towards more compatible, accessible organs for patients.<\/i><\/p><p style=\"text-align: center;\"><span style=\"color: #999999;\">\u00a0Posted: 8 October, 2025<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29671345 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29671345\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c4c2844\" data-id=\"7c4c2844\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-197ae4d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"197ae4d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2aa5432 elementor-widget elementor-widget-image\" data-id=\"2aa5432\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"480\" height=\"97\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Avivo_Logo_Red_RGB.jpg\" class=\"attachment-medium_large size-medium_large wp-image-27719\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Avivo_Logo_Red_RGB.jpg 480w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Avivo_Logo_Red_RGB-300x61.jpg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Avivo_Logo_Red_RGB-18x4.jpg 18w\" sizes=\"(max-width: 480px) 100vw, 480px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e2aed3 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"56e2aed3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In a world-first, researchers have successfully transplanted a donor kidney after converting it from blood type A to the universal type O, removing one of the biggest barriers in organ donation: blood-type compatibility. The landmark study, published in <a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41551-025-01513-6&amp;esheet=54333912&amp;newsitemid=20251006694316&amp;lan=en-US&amp;anchor=Nature+Biomedical+Engineering&amp;index=1&amp;md5=96861e6bb8b6dd1889c4eab843eb6187\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\"><i>Nature Biomedical Engineering<\/i><\/a>, was led by Dr. Turun Song at West China Hospital in Chengdu, in partnership with the University of British Columbia (UBC) and Vancouver-based\u00a0<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Favivobio.com%2F&amp;esheet=54333912&amp;newsitemid=20251006694316&amp;lan=en-US&amp;anchor=Avivo+Biomedical+Inc.&amp;index=2&amp;md5=ac23822c887282374d43e544d1f40fec\" target=\"_blank\" rel=\"nofollow noopener\" shape=\"rect\">Avivo Biomedical Inc.<\/a> (Avivo), a GlycoNet-supported startup.<\/p><p><strong>Transforming Transplant Medicine<br \/><\/strong>More than 3,500 Canadians and 100,000 Americans await lifesaving organ transplants, yet many donor organs go unused due to blood-type mismatch. Researchers in this study used a proprietary enzyme system, discovered at UBC and being developed by Avivo, to convert a type A kidney to type O. The resulting Enzyme-Converted type-O (ECO) kidney was transplanted into a brain-dead, blood type\u2013mismatched recipient using standard clinical protocols.<\/p><p>Key findings include:<\/p><ul class=\"bwlistdisc\"><li>No hyperacute rejection was observed.<\/li><li>The ECO kidney retained its physiological function post-transplant.<\/li><\/ul><p>\u201cThis is the first time a type A human kidney has been converted to ECO and successfully transplanted into a mismatched recipient,\u201d said John Coleman, CEO of Avivo. \u201cPublication in\u00a0<i>Nature Biomedical Engineering<\/i>\u00a0underscores the significance of this breakthrough and its potential to transform organ transplantation. By enabling every donor organ to become universally compatible, our ECO platform has the potential to save more lives and reduce waitlist mortality.\u201d<\/p><p><b>The Path to Universal Organ Access<br \/><\/b>The ability to convert donor kidneys \u2013 and ultimately other organs \u2013 into type O could dramatically expand the donor pool, reduce waitlist mortality, and ensure more equitable access to lifesaving transplants.<\/p><p>The decedent transplant model used in this study is particularly compelling, as it replicates real transplant conditions, including blood flow, immune response, and surgical handling, without exposing living patients to risk. Originally pioneered for xenotransplantation, the decedent model is recognized by the FDA as a pathway towards clinical trials. With these results, Avivo plans additional studies to evaluate longer-term graft survival.<\/p><p><a href=\"https:\/\/www.businesswire.com\/news\/home\/20251006694316\/en\/Worlds-First-Blood-Type-A-to-O-Kidney-Transplant-Achieved-by-Avivo-and-UBC-Researchers\">Original Source: Business Wire Press Release<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-648be10 elementor-widget elementor-widget-shortcode\" data-id=\"648be10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><div style=\"position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%;\">\n  <iframe src=\"https:\/\/embed.jasperplayer.com?brand=CTV_NEWS&destination=ctvnews_web&language=EN&contentId=3233277\"\n          style=\"position: absolute; top: 0; left: 0; width: 100%; height: 100%; border: 0;\"\n          allow=\"autoplay; clipboard-write; encrypted-media; picture-in-picture\"\n          allowfullscreen>\n  <\/iframe>\n<\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b845273 elementor-widget elementor-widget-text-editor\" data-id=\"b845273\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.ctvnews.ca\/vancouver\/article\/ubc-enzyme-technology-successfully-completes-first-human-trial-for-universal-organ-transplants\/\">Full CTV News Article<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bf3619 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9bf3619\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7590d33a elementor-widget elementor-widget-text-editor\" data-id=\"7590d33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de GlycoNet<\/a><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256dce24 elementor-widget elementor-widget-spacer\" data-id=\"256dce24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a86c32 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a86c32\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0f43794\" data-id=\"0f43794\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>The successful transplant marks major progress towards more compatible, accessible organs for patients.<\/p>","protected":false},"author":7,"featured_media":27746,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[204,203,4],"tags":[360,7,250,361],"class_list":["post-27718","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-community","category-research-highlight","category-success-stories","tag-avivo","tag-glyconet","tag-transplantation","tag-universal-donor-organs","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"The successful transplant marks major progress towards more compatible, accessible organs for patients.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Aalyssa 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