{"id":6348,"date":"2015-11-16T15:41:42","date_gmt":"2015-11-16T22:41:42","guid":{"rendered":"http:\/\/canadianglycomics.ca\/?p=6348"},"modified":"2019-07-31T14:53:13","modified_gmt":"2019-07-31T20:53:13","slug":"avoiding-neutrophil-traps-how-an-invasive-fungus-defeats-the-mammalian-immune-response","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/avoiding-neutrophil-traps-how-an-invasive-fungus-defeats-the-mammalian-immune-response\/","title":{"rendered":"Avoiding neutrophil traps: How an invasive fungus defeats the mammalian immune response"},"content":{"rendered":"
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Scanning electron microscopy illustrates the difference in the abundance of cell wall-associated galactosaminogalactan (arrows) between the opportunistic fungal pathogen Aspergillus fumigatus and the minimally pathogenic species Aspergillus nidulans. (Photo credit: Lee et al. (2015))<\/figcaption><\/figure>\n

Invasive aspergillosis (IA) is a serious disease of immune-compromised individuals and the most common invasive mold infection in humans. Although more than 250 different\u00a0Aspergillus<\/i> species are found in nature, and most contribute spores to the air we breathe, over 80% of human disease is caused by one particular culprit called\u00a0Aspergillus fumigatus<\/i>. A study published<\/a> on October 22nd in PLOS Pathogens<\/i> explores what distinguishes this fungus from its relatives and likely makes it so dangerous.<\/p>\n

GlycoNet researcher Donald Sheppard, from the Research Institute of the McGill University Health Centre in Montreal, Canada, and colleagues set out to explore features that could facilitate infection by A. fumigatus<\/i> as compared with less pathogenic Aspergillus\u00a0<\/i>species. Because they and others had previously identified a particular sugar in the cell wall of A. fumigatus<\/i> called GAG, short for “galactosaminogalactan”, as critical to the fungus’ ability to outwit the host immune system, the researchers started by testing whether differences in GAG production contribute to differences in the virulence (i.e. the ability to cause disease) observed among Aspergillus\u00a0<\/i>species.<\/p>\n

Comparing A. fumigatus<\/i> with the less pathogenic species A. nidulans<\/i>, they found that the amount of cell wall-associated GAG correlated with the reported virulence of these species. Further experiments suggested that the production of high levels of cell wall-associated GAG makes A. fumigatus<\/i> more resistant than A. nidulans<\/i> to neutrophil killing by neutrophil extracellular traps, or NETs (NETs are are networks of extracellular fibers, composed of DNA and proteins secreted by immune cells called neutrophils, that bind and trap various pathogens).<\/p>\n

Increasing cell wall-associated GAG in A. nidulans<\/em> enhanced resistance to NETs and increased the virulence of this species to the same level as A. fumigatus<\/i> in immune-compromised mice with intact NET formation. Collectively, these data suggest that A. nidulans<\/i> is more sensitive than A. fumigatus<\/i> to NETs due to lower overall levels of cell wall-associated GAG.<\/p>\n

Their study, the researchers say “establishes a role for cell wall-associated GAG in mediating resistance to killing of Aspergillus<\/i> by NETs and provides the first example of a virulence factor of A. fumigatus<\/i> that is able to mediate enhanced virulence when expressed in a less pathogenic Aspergillus<\/i> species”. As their results highlight the importance of GAG as a key virulence factor of A. fumigatus<\/i>, they suggest that targeting GAG may be an effective antifungal approach in some human patients.<\/p>\n

This article is republished from PLOS Pathogens<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

GlycoNet researcher Donald Sheppard, from the Research Institute of the McGill University Health Centre in Montreal, Canada, and colleagues set out to explore features that could facilitate infection by A. fumigatus as compared with less pathogenic Aspergillus\u00a0species.<\/p>","protected":false},"author":2,"featured_media":12203,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-6348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t