{"id":9601,"date":"2018-07-04T09:01:09","date_gmt":"2018-07-04T15:01:09","guid":{"rendered":"http:\/\/canadianglycomics.ca\/?p=9601"},"modified":"2021-01-27T19:59:04","modified_gmt":"2021-01-28T02:59:04","slug":"a-pretty-plant-of-summer-produces-a-promising-anti-diabetes-compound","status":"publish","type":"post","link":"https:\/\/canadianglycomics.ca\/fr\/a-pretty-plant-of-summer-produces-a-promising-anti-diabetes-compound\/","title":{"rendered":"A pretty plant of summer produces a promising anti-diabetes compound"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9601\" class=\"elementor elementor-9601\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ff8d86b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ff8d86b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ce518a7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4643eff2\" data-id=\"4643eff2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1da8f3f5 elementor-widget elementor-widget-spacer\" data-id=\"1da8f3f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f49978c elementor-widget elementor-widget-text-editor\" data-id=\"6f49978c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2 style=\"text-align: center;\">A pretty summer plant produces a promising anti-diabetes compound<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b0fb1ac elementor-widget elementor-widget-text-editor\" data-id=\"2b0fb1ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #999999;\">Jennifer Lockhart \u2022 Posted: July 2, 2018<\/span><\/p><p style=\"text-align: center;\">Discovery of the biosynthetic pathway of a plant metabolite lays the groundwork for its use as an anti-diabetes drug.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1772d081 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1772d081\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-66cde845\" data-id=\"66cde845\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ac933f elementor-widget elementor-widget-text-editor\" data-id=\"3ac933f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6>Montbretin A (MbA), a natural compound with great potential for the treatment of type-2 diabetes, was discovered in the ornamental plant montbretia ten years ago, but it can\u2019t be produced on a large scale until its biosynthesis is understood. Canadian scientists discovered genes and enzymes responsible for MbA biosynthesis and demonstrated the potential for metabolic engineering of wild tobacco to produce this promising drug candidate.<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1924de2d elementor-widget elementor-widget-image\" data-id=\"1924de2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Bohlmann-withers-01-1024x683.jpg\" class=\"attachment-large size-large wp-image-15990\" alt=\"\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Bohlmann-withers-01-1024x683.jpg 1024w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Bohlmann-withers-01-300x200.jpg 300w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Bohlmann-withers-01-768x513.jpg 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Bohlmann-withers-01-16x12.jpg 16w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/Bohlmann-withers-01.jpg 1413w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">GlycoNet Investigators Joerg Bohlmann (left) and Stephen Withers (right) from the University of British Columbia.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6518341b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6518341b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5cd03fb2 elementor-widget elementor-widget-text-editor\" data-id=\"5cd03fb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Roughly half of the western medicines used today were derived from naturally occurring plant metabolites. Plants produce over 200,000 of these specialized metabolites, but identifying medicinally useful ones is challenging, and obtaining sufficient quantities for human use poses an even greater challenge. Type-2 diabetes, a disease characterized by elevated blood glucose levels due to the body\u2019s inefficient use of insulin, affects over 320 million people worldwide. Drugs that are commonly used to treat type-2 diabetes reduce blood glucose levels by inhibiting the activities of two enzymes: HPA (pancreatic alpha-amylase), which cleaves complex starches into strings of sugar molecules called oligosaccharides and alphaglucosidases, which convert oligosaccharides into glucose in the gut. Unfortunately, the inhibition of alpha-glucosidases causes some undigested oligosaccharides to move into the lower bowel, leading to flatulence and diarrhea.<\/p><p><img decoding=\"async\" class=\"alignright wp-image-15991 size-medium\" src=\"http:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant-231x300.png\" alt=\"\" width=\"231\" height=\"300\" srcset=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant-231x300.png 231w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant-788x1024.png 788w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant-768x999.png 768w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant-1181x1536.png 1181w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant-9x12.png 9w, https:\/\/canadianglycomics.ca\/wp-content\/uploads\/plant.png 1209w\" sizes=\"(max-width: 231px) 100vw, 231px\" \/><\/p><p>Ten years ago, in an effort to produce a diabetes drug that specifically inhibits HPA activity without having nasty side effects, scientists screened 30,000 extracts derived from plants and other organisms and found a single compound that fit the bill: montbretin A (MbA) from the bulb-like underground corms of the ornamental plant montbretia (Crocosmia x crocosmiiflora) (see figure). Unfortunately, MbA can\u2019t be produced in large quantities without understanding the biochemical pathway and genes involved in its biosynthesis, a difficult task considering the diversity and complexity of plant metabolic pathways.<\/p><p>Scientists from the University of British Columbia and the Canadian Glycomics Network analyzed this crucial pathway, as discussed in this month\u2019s issue of The Plant Cell. The scientists discovered the first three intermediate metabolites in the MbA biosynthesis pathway, including a product called mini-MbA, which also strongly inhibits HPA activity, as well as the four enzymes involved in mini-MbA production. Importantly, when they cloned the genes for these enzymes and used them to genetically transform wild tobacco, they successfully obtained mini-MbA. According to lead scientist Dr. Joerg Bohlmann of the University of British Columbia, Vancouver BC, \u201cThis is a fascinating example of the largely undiscovered potential of plant specialized metabolism that may lead to new treatments for the improvement of human health\u201d.<\/p><p>The research was supported with funds from the GlycoNet, the Natural Sciences and Engineering Research Council of Canada (NSERC), and the Canadian Institutes for Health Research, as well as the Alexander von Humboldt foundation through a Feodor Lynen Research Fellowship, the UBC Genome Science and Technology (GSAT) Graduate Program, and an NSERC Canada Graduate Scholarship-Master\u2019s, and the British Columbia Epilepsy Society.<\/p><p><b>Full citation: <\/b>Irmisch, S., Jo, S., Roach, C.R., Jancsik, S., Yuen, M.M.S., Madilao, L.L, O&#8217;Neil-Johnson, M., Williams, R., Withers, S.G., and Bohlmann, J. (2018). Discovery of UDP-Glycosyltransferases and BAHDAcyltransferases Involved in the Biosynthesis of the Anti-Diabetic Plant Metabolite Montbretin. Plant Cell 10.1105\/tpc.18.00406.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a7b864e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4a7b864e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51925e05 elementor-widget elementor-widget-text-editor\" data-id=\"51925e05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6 style=\"text-align: center;\">Plus de <a href=\"http:\/\/canadianglycomics.ca\/fr\/news-events\/\">nouvelles de 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data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-607a14ed elementor-widget elementor-widget-text-editor\" data-id=\"607a14ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/contact\/\"><b>Contact<\/b><\/a><\/span><\/p><p><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/forum.glyconet.ca\/index.php\/Main_Page\"><b>Forum<\/b><\/a><\/span><br \/><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"http:\/\/canadianglycomics.ca\/fr\/forum-help-and-faqs\/\">Aide pour le Forum et FAQ<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-16 elementor-top-column elementor-element elementor-element-29e7a83d\" data-id=\"29e7a83d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46f30c20 elementor-widget elementor-widget-image\" data-id=\"46f30c20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"297\" height=\"95\" src=\"https:\/\/canadianglycomics.ca\/wp-content\/uploads\/GlycoNet_logo_landscape_white-1.png\" class=\"attachment-large size-large wp-image-11877\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2622cd9e elementor-widget elementor-widget-text-editor\" data-id=\"2622cd9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>R\u00e9seau Canadien de la Glycomique<br \/>E5-33 Gunning\/Lemieux Chemistry Centre<br \/>University of Alberta, T6G 2G2<br \/>T\u00e9l.: 780-492-6204<br \/>T\u00e9l\u00e9c.: 780-492-4147<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-53e50015 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"53e50015\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2f8d895b\" data-id=\"2f8d895b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c4a0d60 elementor-widget elementor-widget-text-editor\" data-id=\"1c4a0d60\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a9 R\u00e9seau Canadien de la Glycomique (GlycoNet). Tous droits r\u00e9serv\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Discovery of the biosynthetic pathway of a plant metabolite lays the groundwork for its use as an anti-diabetes drug.<\/p>","protected":false},"author":2,"featured_media":11412,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[203],"tags":[],"class_list":["post-9601","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlight","wpbf-post"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"Discovery of the biosynthetic pathway of a plant metabolite lays the groundwork for its use as an 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