GlycoNet has centralized research facilities to provide access to technical expertise. These core services allow researchers to access essential scientific infrastructure at a reasonable cost that would otherwise be cost prohibitive. Our core services include:
We offer a unique set of services and expertise for solving your problems in glycomics research. We are experienced in the analysis of complex glycans and glycoproteins and can provide routine analysis or help to interpret complex data.
- Routine characterization of oligosaccharide samples for QC and analysis
- Complex structure determination, including high-resolution conformational analysis and protein-carbohydrate complexes
- 1D/2D NMR (300, 400, 500, 600, 700 MHz), STD-NMR
- Compositional analysis (stoichiometry) of polysaccharides
- Oligosaccharide/Glycan sequencing
- Determination of unusual or modified glycan structures
- Nano-ES, MALDI TOF/TOF, FT-ICR
- Molecular dynamics of glycoproteins and protein-carbohydrate complexes
- AMBER (GLYCAM)
- Surface Plasma Resonance (BIAcore)
Glycan analysis is often complex and can require advanced training. We will work with you to interpret data from even your most complex samples.
Glycan Screening Facility
The Glycan Screening Facility uses advanced electrospray ionization mass spectrometry (ESI-MS) instrumentation and methods to screen carbohydrate libraries and other classes of compounds against target proteins. This can be used to identify novel inhibitors and natural receptors for developing new and effective treatments for a variety of diseases including bacterial and viral infections.
Our carbohydrate collection includes over 250 compounds (including ABH and Lewis histogroup antigens, human milk oligosaccharides, gangliosides, and plant and bacterial oligosaccharides). The Glycan Screening Facility is dedicated to developing novel ESI-MS methods which allow identification, characterization, and quantification of protein-carbohydrate interactions in vitro. Researchers may access the Glycan Screening Facility through research collaborations or on a fee-for-service basis.
48Hour Discovery Inc.
48Hour Discovery Inc. launched as a self-sustaining company in February 2017 with the support of GlycoNet, in partnership with the Alberta Glycomics Centre. This accelerated service is designed to help academia and industry in molecular discovery in the areas of therapeutics, diagnostics, and probe development.
At 48Hour Discovery, a client mails the protein solution for analysis and in as few as forty-eight hours later, scientists provide a list of molecules that bind to the protein. The screening services provide risk management, expert analysis and partnerships with the Network’s academic and industrial collaborators.