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Recently Announced Projects

Strategic Initiatives

Positron emission tomography (PET) for imaging glucocerebrosidase within brain
Investigators: David Vocadlo (Simon Fraser University), Vesna Sossi (University of British Columbia), Paul Schaffer (TRIUMF)

Activity-based probes to study GBA and GBA2 in Parkinson’s Disease
Investigators: Christopher Phenix (University of Saskatchewan), Aarnoud Van Der’Spoel (Dalhousie University)

Selective GBA2 inhibitors and their evaluation in cell models of Batten Disease
Investigators: David Vocadlo (Simon Fraser University), Lisa Julian (Simon Fraser University)

Modulating CD33 splicing as a protective therapeutic strategy in Alzheimer’s disease
Investigator: Matthew Macauley (University of Alberta)

Bringing a candidate Haemophilus influenzae serotype A vaccine through late pre-clinical development into a phase I, randomized, placebo-controlled, observer-blind trial
Investigators: Brian Ward (McGill University), Scott Halperin (Dalhousie University), Joanne Langley (Dalhousie University)

Inhibitors of antibody fucosylation: commercialization-enabling studies
Investigators: Robert Britton (Simon Fraser University), David Vocadlo (Simon Fraser University)

Elucidating the role of somatostatin in dysglycemia in a rodent model of type 2 diabetes
Investigators: Michael Riddell (York University), Richard Liggins (Zucara Therapeutics), Owen Chan (University of Utah)

Towards universal blood through enzymatic red blood cell modification
Investigators: Stephen Withers (University of British Columbia), Jayachandran Kizhakkedathu (University of British Columbia)

Translational Grants

Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy
Investigators: Sachiko Sato (Université Laval), Masahiko Sato (Université Laval), Jerome Frenette (Université Laval)

Clinical trial for montbretin A in diabetics
Investigators: Stephen Withers (University of British Columbia), J.P. Heale (University of British Columbia), Robert Petrella (University of British Columbia), Joerg Bohlmann (University of British Columbia)

International Partnerships Grant

Engineering the enzymatic synthesis of oligosaccharides to prove the role of internalized glycans
Investigators: David Kwan (Concordia University), Ching-Ching Yu (National Chung Cheng University), Chun-Hung Lin (Academia Sinica)

Clinical Partnerships Grants

Gangliosides in the cerebrospinal fluid as potential disease biomarkers in patients with Huntington’s disease
Investigators: Simonetta Sipione (University of Alberta), Oksana Suchowersky (University of Alberta), Jonathan Curtis (University of Alberta)

Improvement of CAR T-cell therapy through glycoengineering
Investigators: Lisa Willis (University of Alberta), Michael Chu (University of Alberta)

Canadian Glycomics Network
E5-33 Gunning/Lemieux Chemistry Centre
University of Alberta, T6G 2G2
Tel: 780-492-6204
Fax: 780-492-4147

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