Dr. Hendel’s research group focuses on two research streams: the scalable isolation of N-glycans from natural sources and the development of synthetic methodologies to access glycomimetics. The first stream aims to improve access to well-characterized glycans, which are essential for biopharmaceutical development and investigating changes in glycosylation associated with disease. Drawing on my experience in the biotechnology industry, we are developing practical and scalable methods for isolating complex N-glycans to improve their availability as standards and starting materials for semi-synthesis. Our second research stream focuses on developing synthetic methodologies to access glycomimetics containing non-natural structural modifications, with the aim of generating molecular probes for investigating interactions with glycan-binding proteins. This presentation will highlight recent progress and challenges in both research areas.
| No. overall | Speakers & titles | |
|---|---|---|
| 66 |
Dr. Jean-Philippe Julien, University of Toronto Protein and glycan engineering for next-generation malaria vaccines |
|
| 65 |
Dr. Mariela Segura, University of Montreal Glycoscience for One Health: From Bacterial Capsules to Better Vaccines |
|
| 64 |
Dr. Landon Edgar, University of Toronto The Glycocalyx as a Nexus of Control Over Human T Cell Immunophysiology |
|
| 63 |
Dr. Charles Gauthier, Institut National de la Recherche Scientifique (INRS)
Total Synthesis of Burkholderia-Inspired Glycans: From Vaccines to Biosurfactants |
|
| 62 |
Dr. David Vocadlo, Simon Fraser University
Chemical biology tools for probing and perturbing carbohydrate processing enzymes in mammalian systemss |
|
| 61 |
Dr. Eric Brown, McMaster University
Starving Bacteria to Find New Antibodies |
|
| 60 |
Dr. Darrell Mousseau, University of Saskatchewan
The brain organoid: a window into the donor's brain |
|
| 59 |
Dr. Duong Bui, University of Alberta
Cracking the Glycan Code with Native Mass Spectrometry |
| No. overall | Speakers & titles |
|---|---|
| 50 |
Dr. Warren Wakarchuk, University of Alberta
Custom Glycomics Solutions with GlycoNet Integrated Services |
| 51 |
Dr. Sicheng Lin, University of Alberta & Dr. François Le Mauff, Research Institute of the McGill University Healthcare Centre
Glycomics Analysis & Synthesis with GlycoNet Integrated Services |
| 52 |
Dr. Lisa Willis, University of Alberta
Polysialic acid is associated with T cell activation and controls migration |
| 53 |
Dr. David Vocadlo, Simon Fraser University
Live cell imaging substrates for quantifying glycoside hydrolase activities within cells |
| 54 |
Dr. Matthew Macauley & Dr. Edward Schmidt, University of Alberta
New tools to study glycan ligands of Siglecs |
| 55 |
Dr. Kelly McNagny, University of British Columbia
Innate Lymphoid cells as Sculptors of Long Term Immune Response and Drivers of Chronic Inflammation |
| 56 |
Dr. Stephen Withers, University of British Columbia
Recent developments in the discovery and engineering of bacterial glycoside hydrolases using high-throughput approaches |
| 57 |
Dr. Anna Blakney, University of British Columbia
Next generation RNA vaccines & therapies |
| 58 |
Dr. Yves St-Pierre, Institut national de la recherche scientifique
Molecular and Cellular Biology Facility (MCBF): Integrated Platforms for Nanobody, Cellular, and Omics Research |
| No. overall | Speakers & titles |
|---|---|
| 49 |
Dr. Harry Brumer, University of British Columbia
Adventures in the human gut microbiota: Characterization and applications of complex carbohydrate utilization systems Dr. Simon Wisnovsky, University of British Columbia Revealing functional ligands for glycan-binding immune receptors with genome-wide CRISPR screening |
| No. overall | No. in season | Speakers & titles |
|---|---|---|
| 21 | 1 |
Dr. Lara Mahal, Professor, University of Alberta Exploring the roles of glycosylation in infection and immunity Dr. Peter Rahfeld, Research Associate, University of British Columbia From gut to blood: how to make universal donor blood |
| 22 | 2 |
Dr. Mary Cloninger, Professor, Montana State University Lactose-functionalized dendrimers and dendritic polyglycerols for binding to galectin-3 Dr. Pumtiwitt McCarthy, Associate Professor, Morgan State University Bacterial capsule polymerases as tools to improve human health |
| 23 | 3 |
Dr. Warren Wakarchuk, Professor, University of Alberta Protein engineering of 21st century drugs through the application of synthetic biology Dr. Landon Edgar, Post-doctoral fellow, Scripps Research Invigorating T cells through carbohydrate editing |
| 24 | 4 |
Dr. Theresa M. Reineke, Professor, University of Minnesota Glycopolymers promote in vivo and ex vivo delivery of functional nucleic acids Dr. Jodi Hadden-Perilla, Assistant Professor, University of Delaware The fuzzy boundaries of carbohydrate binding sites |
| 25 | 5 |
Dr. Mark Nitz, Professor, University of Toronto Exploring a low affinity probe for the biofilm-associated poly-N-acetylglycosamine exopolysaccharide Dr. Sandra Irmisch, Research Associate, University of British Columbia A novel anti-diabetic compound from plants: biosynthesis, gene discovery, and metabolic engineering of montbretin A |
| 26 | 6 |
Dr. Mingdi Yan, Professor, University of Massachusetts Lowell Carbohydrate-conjugated fluorescence turn-on azide probes for imaging cells and bacteria Dr. Jessica Kramer, Assistant Professor, University of Utah Synthetic mucins: from new chemical routes to engineered cells |
| 27 | 7 |
Dr. David Vocadlo, Professor, Simon Fraser University Fluorescence-quenched substrates for monitoring glycoside hydrolase activities in mammalian cells Dr. Simonetta Sipione, Professor, University of Alberta Gangliosides in neurodegeneration and neuroinflammation |
| No. overall | No. in season | Speakers & titles |
|---|---|---|
| 13 | 1 |
Dr. Parastoo Azadi, Executive Director, Analytical Services, Complex Carbohydrate Research Centre Glycobiology of SARS-CoV2 and its implications for vaccine development Dr. Supriya Dey, Post-Doctoral Fellow, Harvard University Programmable one-pot synthesis of heparin and heparin-related anticoagulants |
| 14 | 2 |
Dr. Robert Ben, Professor, University of Ottawa Improving the efficacy of modern cellular therapies Dr. François Le Mauff, Post-Doctoral Fellow, McGill University Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for aspergillus fumigatus biofilm formation |
| 15 | 3 |
Dr. David Pamer, Professor, University of Saskatchewan Writing an effective grant proposal |
| 16 | 4 |
Dr. David Kwan, Assistant Professor, Concordia University A set of chemical biology tools to probe and inhibit cellular glycosyltransferases Shermaine Sy, B.Sc, University of Alberta Development of a bead-based assay for ABO antibody detection: creating a new tool for the clinical laboratory |
| 17 | 5 |
Drs. Kate Pratt and Jonathon Simmons, Academic Success Centre, University of Alberta A workshop for scientific writers |
| 18 | 6 |
Dr. Chris Phenix, Assistant Professor, University of Saskatchewan Chemical tools for studying glucosidase activity in complex biological samples F. Ifthiha Mohideen, Graduate Student, Concordia University An engineered in vitro enzymatic pathway for the anticancer anthracycline deoxysugars: TDP-L-acosamine and TDP-L-daunosamine |
| 19 | 7 |
Dr. Rebecca Davis, Associate Professor, University of Manitoba Computational approaches for designing small molecule inhibitors |
| 20 | 8 |
Dr. Robert Britton, Professor, Simon Fraser University De novo synthesis of nucleoside analogues for medicinal chemistry purposes Dr. Kristen Low, Post-Doctoral Fellow, Agriculture and Agri-Food Canada Bioprospecting CAZymes from intestinal microbiomes for the tailored degradation of non-starch dietary polysaccharides |
| No. overall | No. in season | Speakers & titles |
|---|---|---|
| 1 | 1 |
Dr. Christopher Cairo, Associate Professor, University of Alberta Inhibitors of human neuraminidase enzymes as probes in glycobiology Mirat Sojitra, Graduate Student, University of Alberta Genetically encoded multivalent liquid glycan array (LiGA) |
| 2 | 2 |
Dr. Andrew Lees, Founder and Scientific Director, Fina Biosolutions Simplifying conjugation: ready to conjugate CRM197 carrier protein |
| 3 | 3 |
Dr. Robert Woods, Professor, University of Georgia 3D models of glycosylated SARS-CoV-2 protein suggest challenges for vaccine development Dr. Jolene Garber, Post-Doctoral Fellow, University of British Columbia Okanagan Campylobacter jejuni chemotaxis and metabolism of fucose |
| 4 | 4 |
Dr. Lori Yang, CEO & CSO, Lectenz Bio Lectenz and GlycoSense: novel tools for glycan detection and analysis |
| 5 | 5 |
Dr. Matt Macauley, Assistant Professor, University of Alberta Modulation of microglia by the glycan-binding protein CD33 Carla Eymard, Graduate Students, Institut de recherches cliniques de Montreal From free radical chemistry to novel classes of bioactive modified furanosides |
| 6 | 6 |
Dr. Anne Krook, Practical Workplace Advice A guide to non-academic job search |
| 7 | 7 |
Dr. Karla Williams, Assistant Professor, University of British Columbia Polysialic acid as a prognostic marker in breast cancer Sadia Rahmani, Graduate Student, Ryerson University O-GlcNAc modification affects clathrin-coated pit assembly and efficiency at the plasma membrane |
| 8 | 8 |
Panel Discussion ft. Drs. David Vocadlo, Stephanie White, and Kaley Wilson What I wish I knew: a chat with researchers, patent experts and entrepreneurs |
| 9 | 9 |
Dr. Lynne Howell, Professor, The Hospital for Sick Children Exopolysaccharide biosynthesis Dr. Ryan Sweeney, Post-Doctoral Fellow, University of Alberta Development of an active site titration reagent for amylases |
| 10 | 10 |
Andrew MacIsaac, CEO, Applied Pharmaceutical Innovation Navigating commercial development with API |
| 11 | 11 |
Dr. Molly Shoichet, Professor, University of Toronto Polysaccharide hydrogels enable local drug and cell delivery Akay Akohwarien, Research Technician, University of Saskatchewan Designing novel chemical tools to study β-glucocerebrosidase: a relevant biomarker and therapeutic target in Parkinson's Disease |
| 12 | 12 |
Sabrina Sassi, TEDx Speaker Leveraging TED to spread your research ideas: how and why researchers are doing it |