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Season 2

S02E06. August 12, 2020
11 am – 12 pm
SEMINAR

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Chemical tools for studying glucosidase activity in complex biological samples

Dr. Chris Phenix,
Assistant Professor, University of Saskatchewan

Dr. Chris Phenix obtained his Ph.D. from the University of Saskatchewan under the supervision of Dr. David Palmer in the Department of Chemistry. There he studied the biochemical role of an enzyme found in Sinorhizobium meliloti, a bacteria used as a nitrogen inoculants for leguminous crops. He then went on to postdoctoral studies at UBC/TRIUMF under the supervision of Drs. Stephen Withers, Tom Ruth and Michael Adam. There he worked on the radiochemical synthesis of agents to 18F label β-glucosidases using a mechanism-based approach. The intent of such agents is to PET image the in vivo biodistribution and pharmacokinetics of an exogenously administered β-glucosidase, Glucocerebrosidase, the therapeutic enzyme used for direct enzyme replacement therapy of Gaucher disease. Currently he is a scientist at the Thunder Bay Regional Research Institute and Assistant Professor at the Northern Ontario School of Medicine. He is also an adjunct in Chemistry at Lakehead University. His research is focused on developing probes for PET imaging enzymes important for human health including glucosidases involved in Parkinson’s and other diseases.

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An engineered in vitro enzymatic pathway for the anticancer anthracycline deoxysugars: TDP-L-acosamine and TDP-L-daunosamine

F. Ifthiha Mohideen,
Graduate Student, Concordia University

Ifthiha is a Ph.D. Candidate in the laboratory of Dr. David Kwan at Concordia University. Her doctoral research focuses on the function and engineering of enzymes involved in the glycosylation of natural products. In particular, she is interested in developing a method for assaying glycosyltransferases in a high-throughput fashion and engineering a novel in vitro enzymatic pathway for the anticancer anthracycline deoxysugars. Before joining Concordia, Ifthiha obtained her B.Sc. (Honors) in Plant Biotechnology from the University of Colombo, Sri Lanka in 2014.

S02E07. August 19, 2020
11 am – 12 pm
TECHNICAL WORKSHOP

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Workshop: Computations approaches for designing small molecule inhibitors

Dr. Rebecca Davis,
Associate Professor, University of Manitoba

Workshop Summary

This workshop will provide the theoretical background as well as discussion of the current approaches to Molecular Docking and Virtual screening. The workshop will also discuss the different software available and will focus on Cheminformatics methods for lead identification and optimization.

Speaker

Dr. Rebecca Davis is an organic chemist at The University of Manitoba. Her research is focused on exploring of the mechanisms of asymmetric organocatalytic reactions and broadening the range of organic reactions in which asymmetric organocatalysis can be applied. Dr. Davis current research topics include: mechanisms in asymmetric phase transfer catalysis; counter-ion interactions in non-covalent organocatalysis; and development of stereoselective rearrangement reactions. Dr. Rebecca Davis obtained her Ph.D at the University of California, Davis, and conducted Postdoctoral Research at The Centre for Catalysis at Aahus University.

S02E08. August 26, 2020
11 am – 12 pm
SEMINAR

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De novo synthesis of nucleoside analogues for medicinal chemistry purposes

Dr. Robert Britton,
Professor, Simon Fraser University

Professor Robert Britton obtained his B. Sc. from the University of Waterloo in 1996 working with Professor Victor Snieckus, and his Ph. D. in natural product isolation, structural elucidation, and total synthesis from the University of British Columbia under the supervision of Professors Edward Piers and Raymond Anderson. He spent two years at the University of Cambridge with Professor Ian Paterson as an NSERC PDF then joined the Process Research Group at Merck as a Senior Scientist before starting an independent career at Simon Fraser University in 2005. He is a Michael Smith Foundation for Health Research Career Scholar and his research program focuses on the concise synthesis of structurally and stereochemically complex natural products and the discovery of new synthetic methods to support drug discovery and development.

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Bioprospecting CAZymes from intestinal microbiomes for the tailored degradation of non-starch dietary polysaccharides

Dr, Kristin Low,
Post-Doctoral Fellow, Agriculture and Agri-Food Canada

Dr. Kristin Low completed her Ph.D in Biochemistry at Queen’s University. Following this, her first postdoctoral fellowship was with Dr. P. Lynne Howell at The Hospital for Sick Children (SickKids) characterizing protein-protein interactions in the alginate acetylation machinery of Pseudomonas aeruginosa. She is currently in Dr. Wade Abbott’s research program at Agriculture and Agri-Food Canada where her research involves investigating the carbohydrate-active enzymatic potential of commensal bacteria of the poultry gastrointestinal tract.

Past Webinars

Season 1

S01E01. April 8, 2020
SEMINAR
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Inhibitors of the human neuraminidase enzymes as probes in glycobiology

Dr. Christopher Cairo
Associate Professor, University of Alberta

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Genetically encoded multivalent liquid glycan array (LiGA)

Mirat Sojitra
Graduate Student, University of Alberta

S01E02. April 15, 2020
INDUSTRY SESSION

Watch Rebroadcast

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Simplifying conjugation: ready to conjugate CRM197 carrier protein

Dr. Andrew Lees
Founder and Scientific Director, Fina Biosolutions LLC

S01E03. April 22, 2020
SEMINAR

Watch Rebroadcast
– Robert Woods
– Jolene Garber

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3D models of glycosylated SARS-CoV-2 protein suggest challenges for vaccine development

Dr. Robert Woods
Professor, University of Georgia

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Campylobacter jejuni chemotaxis and metabolism of fucose

Dr. Jolene Garber
Post-Doctoral Fellow, University of British Columbia Okanagan

S01E04. April 29, 2020
INDUSTRY SESSION

Watch Rebroadcast

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Lectenz® and GlycoSense™: novel tools for glycan detection and analysis

Dr. Lori Yang
CEO & CSO, Lectenz Bio

S01E05. May 6, 2020
SEMINAR
Watch Rebroadcast
– Carla Eymard
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Modulation of microglia by the glycan-binding protein CD33

Dr. Matt Macauley
Assistant Professor, University of Alberta

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From free radical chemistry to novel classes of bioactive modified furanosides

Carla Eymard
Graduate Student, Institut de recherches cliniques de Montreal (IRCM)

S01E06. May 13, 2020
PROFESSIONAL DEVELOPMENT

Watch Rebrodcast

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A guide to non-academic job search

Dr. Anne Krook
Practical Workplace Advice

S01E07. May 20, 2020
SEMINAR
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Polysialic acid as a prognostic marker in breast cancer

Dr. Karla Williams
Assistant Professor, University of British Columbia

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O-GlcNAc modification affects clathrin coated pit assembly and efficiency at the plasma membrane

Sadia Rahmani
Graduate Student, Ryerson University

S01E08. MAY 27, 2020
PANEL DISCUSSION

Watch Rebroadcast

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What I wish I knew: a chat with researchers, patent experts & entrepreneurs
S01E09. June 3, 2020
SEMINAR

Watch Rebroadcast
– Lynne Howell

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Exopolysaccharide biosynthesis

Dr. Lynne Howell
Professor, University of Toronto

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Development of an active site titration reagent for amylases

Dr. Ryan Sweeney
Post-Doctoral Fellow, University of Alberta

S01E10. June 10, 2020
INDUSTRY SESSION

Watch Rebroadcast

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Navigating commercial development with API

Andrew MacIsaac
CEO, Applied Pharmaceutical Innovation

S01E11. June 17, 2020
SEMINAR
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Polysaccharide hydrogels enable local drug & cell delivery

Dr. Molly Shoichet
Professor, University of Toronto

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Designing novel chemical tools to study β-glucocerebrosidase: a relevant biomarker and therapeutic target in Parkinson’s Disease

Akay Akohwarien
Research Technician, University of Saskatchewan

S01E12. June 24, 2020
11 am – 12 pm
PROFESSIONAL DEVELOPMENT
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Leveraging TED to spread your research ideas: how and why researchers are doing it

Sabrina Sassi,
TEDx Speaker

S02E01. July 8, 2020
11 am – 12 pm
SEMINAR

Watch Rebroadcast
– Parastoo Azadi
– Supriya Dey

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Glycobiology of SARS-CoV2 and its implications for vaccine development

Dr. Parastoo Azadi.
Executive Director, Analytical Services, Complex Carbohydrate Research Center (CCRC)

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Programmable one-pot synthesis of heparin and heparin-related anticoagulants

Dr. Supriya Dey,
Post-Doctoral Fellow, Harvard University

S02E02. July 15, 2020
11 am – 12 pm
SEMINAR

Watch Rebroadcast
– Robert Ben
– François Le Mauff

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Improving the efficacy of modern cellular therapies

Dr. Robert Ben,
Professor, University of Ottawa

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Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

Dr. François Le Mauff,
Post-Doctoral Fellow, McGill University

S02E03. July 22, 2020
11 am – 12 pm
PROFESSIONAL DEVELOPMENT

Watch Rebroadcast

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Writing an effective grant proposal

Dr. David Palmer,
Professor, University of Saskatchewan

S02E04. July 29, 2020
11 am – 12 pm
SEMINAR

Watch Rebroadcast
– David Kwan

– Shermaine Sy

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A set of chemical biology tools to probe and inhibit cellular glycosyltransferases

Dr. David Kwan,
Assistant Professor, Concordia University

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Development of a bead-based assay for ABO antibody detection: creating a new tool for the clinical laboratory

Shermaine Sy,
B.Sc., University of Alberta

S02E05. August 5, 2020
11 am – 12:30 pm
PROFESSIONAL DEVELOPMENT
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A workshop for scientific writers

Kate Pratt & Jonathon Simmons
Academic Success Centre, University of Alberta

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